| Literature DB >> 28045524 |
Nicole C Goodwin1, Zhi-Ming Ding, Bryce A Harrison1, Eric D Strobel1, Angela L Harris, Melinda Smith, Andrea Y Thompson, Wendy Xiong, Faika Mseeh, Debra J Bruce, Damaris Diaz, Suma Gopinathan, Ling Li, Emily O'Neill, Mary Thiel, Alan G E Wilson, Kenneth G Carson1, David R Powell, David B Rawlins1.
Abstract
The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared as viable therapeutics to control blood glucose levels in diabetic patents. Herein we report the discovery of LX2761, a locally acting SGLT1 inhibitor that is highly potent in vitro and delays intestinal glucose absorption in vivo to improve glycemic control.Entities:
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Year: 2017 PMID： 28045524 DOI： 10.1021/acs.jmedchem.6b01541
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446