| Literature DB >> 28044252 |
Shilei Wang1, Jie Wu1, Hao Yang1, Xiangyu Liu1, Qiaomu Huang1, Zhong Lu2.
Abstract
Dental caries is a widespread disease mainly caused by the anaerobic oral pathogen Streptococcus mutans (S. mutans). Ag/ZnO nanocomposite is an efficient antibacterial agent because of its high antibacterial activity and low cytotoxicity. In this study, rod-like Ag/ZnO nanocomposite was synthesized through a deposition-precipitation method and characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. The activity of Ag/ZnO nanocomposite against S. mutans was evaluated by determining the minimal inhibitory concentration, minimum bactericidal concentration and growth inhibition curve. The results showed that Ag/ZnO nanocomposite displayed higher activity against S. mutans compared with pure ZnO nanorods. Moreover, the antibacterial mechanism was investigated by determining the bacterial membrane potential, release of K+, intracellular reactive oxygen generation and lipid peroxidation. Disruption of membrane function and oxidation of biomacromolecules played important role in the antibacterial action of Ag/ZnO nanocomposite. This work proposes a potentially effective dental antibacterial agent against the dental caries-causing S. mutans.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28044252 DOI： 10.1007/s10856-016-5837-8
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896