Atabak Kashefimehr1, Reza Pourabbas1,2,3, Masumeh Faramarzi1, Ali Zarandi4,5, Abouzar Moradi1, Howard C Tenenbaum2,3, Amir Azarpazhooh2,3,6. 1. Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2. Faculty of Dentistry, University of Toronto, Toronto, Canada. 3. Department of Dentistry, Mount Sinai Hospital, Toronto, Canada. 4. Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Dr.alizarandi@gmail.com. 5. Department of Periodontics, Tabriz, Islamic Republic of Iran. Dr.alizarandi@gmail.com. 6. Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Canada.
Abstract
BACKGROUND: Peri-implant diseases have been recognized as being among the ever-increasing complications related to dental implants. The aim of this study was to evaluate the adjunctive use of enamel matrix derivative (EMD) to mechanical debridement (MD) in patients with these conditions in terms of clinical parameters and cytokine levels of peri-implant crevicular fluid (PICF). METHODS: In the present double-blind clinical trial, 46 patients with peri-implant mucositis (PM) were randomly divided into control and test groups. Two different therapeutic protocols, consisting of non-surgical MD alone (control group) and MD with the application of EMD (test group), were considered for the two groups. Clinical parameters [bleeding on probing (BOP) and probing depth (PD)] and sampling from PICF were carried out before treatment and 3 months postoperatively. The levels of IL-6 and IL-17 cytokines in PICF were evaluated by enzyme-linked immunosorbent (ELISA). RESULTS: Three-month post-interventional assay revealed significant improvements in BOP and PD in the test group in comparison to the control group (P < 0.0001). Relative to control, IL-6 and IL-17levels were reduced significantly (p < 0.05) in the test group compared to the control group. CONCLUSION: Application of EMD can be considered an adjunct to MD in the non-surgical treatment of PM. However, complete recovery was not observed using either treatment approach showing that management of implant-associated disease is still a significant clinical problem.
RCT Entities:
BACKGROUND: Peri-implant diseases have been recognized as being among the ever-increasing complications related to dental implants. The aim of this study was to evaluate the adjunctive use of enamel matrix derivative (EMD) to mechanical debridement (MD) in patients with these conditions in terms of clinical parameters and cytokine levels of peri-implant crevicular fluid (PICF). METHODS: In the present double-blind clinical trial, 46 patients with peri-implant mucositis (PM) were randomly divided into control and test groups. Two different therapeutic protocols, consisting of non-surgical MD alone (control group) and MD with the application of EMD (test group), were considered for the two groups. Clinical parameters [bleeding on probing (BOP) and probing depth (PD)] and sampling from PICF were carried out before treatment and 3 months postoperatively. The levels of IL-6 and IL-17 cytokines in PICF were evaluated by enzyme-linked immunosorbent (ELISA). RESULTS: Three-month post-interventional assay revealed significant improvements in BOP and PD in the test group in comparison to the control group (P < 0.0001). Relative to control, IL-6 and IL-17 levels were reduced significantly (p < 0.05) in the test group compared to the control group. CONCLUSION: Application of EMD can be considered an adjunct to MD in the non-surgical treatment of PM. However, complete recovery was not observed using either treatment approach showing that management of implant-associated disease is still a significant clinical problem.
Authors: Frank Schwarz; Anton Sculean; Daniel Rothamel; Katja Schwenzer; Thomas Georg; Jürgen Becker Journal: Clin Oral Implants Res Date: 2005-02 Impact factor: 5.977
Authors: M Irshad; N Scheres; D Anssari Moin; W Crielaard; B G Loos; D Wismeijer; M L Laine Journal: J Periodontal Res Date: 2013-02-27 Impact factor: 4.419