Literature DB >> 28039354

Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda.

Patrick Tumwebaze1, Stephen Tukwasibwe1, Aimee Taylor2,3, Melissa Conrad4, Emmanuel Ruhamyankaka1, Victor Asua1, Andrew Walakira1, Joaniter Nankabirwa1, Adoke Yeka5, Sarah G Staedke6, Bryan Greenhouse4, Samuel L Nsobya1, Moses R Kamya1,7, Grant Dorsey4, Philip J Rosenthal4.   

Abstract

We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  K13; Malaria; Plasmodium falciparum; amodiaquine; artemether; artemisinin; artesunate; chloroquine; dihydroartemisinin; drug resistance; lumefantrine; pfcrt; pfmdr1; piperaquine

Mesh：

Substances：

Year:  2017        PMID： 28039354      PMCID： PMC5853976          DOI： 10.1093/infdis/jiw614

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity.

Authors:  Joaniter I Nankabirwa; Melissa D Conrad; Jennifer Legac; Stephen Tukwasibwe; Patrick Tumwebaze; Bonnie Wandera; Simon J Brooker; Sarah G Staedke; Moses R Kamya; Sam L Nsobya; Grant Dorsey; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

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Journal:  Nature       Date:  2013-12-18       Impact factor: 49.962

3.  Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda.

Authors:  George W Mbogo; Sheila Nankoberanyi; Stephen Tukwasibwe; Frederick N Baliraine; Samuel L Nsobya; Melissa D Conrad; Emmanuel Arinaitwe; Moses Kamya; Jordan Tappero; Sarah G Staedke; Grant Dorsey; Bryan Greenhouse; Philip J Rosenthal
Journal:  Am J Trop Med Hyg       Date:  2014-05-05       Impact factor: 2.345

4.  Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy.

Authors:  Abel Kakuru; Prasanna Jagannathan; Mary K Muhindo; Paul Natureeba; Patricia Awori; Miriam Nakalembe; Bishop Opira; Peter Olwoch; John Ategeka; Patience Nayebare; Tamara D Clark; Margaret E Feeney; Edwin D Charlebois; Gabrielle Rizzuto; Atis Muehlenbachs; Diane V Havlir; Moses R Kamya; Grant Dorsey
Journal:  N Engl J Med       Date:  2016-03-10       Impact factor: 91.245

5.  Return of chloroquine antimalarial efficacy in Malawi.

Authors:  Miriam K Laufer; Phillip C Thesing; Nicole D Eddington; Rhoda Masonga; Fraction K Dzinjalamala; Shannon L Takala; Terrie E Taylor; Christopher V Plowe
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6.  Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.

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7.  Emergence of a dhfr mutation conferring high-level drug resistance in Plasmodium falciparum populations from southwest Uganda.

Authors:  Caroline Lynch; Richard Pearce; Hirva Pota; Jonathan Cox; Tarekegn A Abeku; John Rwakimari; Inbarani Naidoo; James Tibenderana; Cally Roper
Journal:  J Infect Dis       Date:  2008-06-01       Impact factor: 5.226

Review 8.  The interplay between drug resistance and fitness in malaria parasites.

Authors:  Philip J Rosenthal
Journal:  Mol Microbiol       Date:  2013-08-16       Impact factor: 3.501

9.  Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.

Authors:  Aimee R Taylor; Jennifer A Flegg; Samuel L Nsobya; Adoke Yeka; Moses R Kamya; Philip J Rosenthal; Grant Dorsey; Carol H Sibley; Philippe J Guerin; Chris C Holmes
Journal:  Malar J       Date:  2014-03-17       Impact factor: 2.979

10.  Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial.

Authors:  Adoke Yeka; Ruth Kigozi; Melissa D Conrad; Myers Lugemwa; Peter Okui; Charles Katureebe; Kassahun Belay; Bryan K Kapella; Michelle A Chang; Moses R Kamya; Sarah G Staedke; Grant Dorsey; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2015-11-23       Impact factor: 5.226
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  28 in total

1.  Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa.

Authors:  Chao Xu; Hui Sun; Qingkuan Wei; Jin Li; Ting Xiao; Xiangli Kong; Yongbin Wang; Guihua Zhao; Longjiang Wang; Gongzhen Liu; Ge Yan; Bingcheng Huang; Kun Yin
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191

2.  Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda.

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3.  Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.

Authors:  Manu Vanaerschot; Leonardo Lucantoni; Tao Li; Jill M Combrinck; Andrea Ruecker; T R Santha Kumar; Kelly Rubiano; Pedro E Ferreira; Giulia Siciliano; Sonia Gulati; Philipp P Henrich; Caroline L Ng; James M Murithi; Victoria C Corey; Sandra Duffy; Ori J Lieberman; M Isabel Veiga; Robert E Sinden; Pietro Alano; Michael J Delves; Kim Lee Sim; Elizabeth A Winzeler; Timothy J Egan; Stephen L Hoffman; Vicky M Avery; David A Fidock
Journal:  Nat Microbiol       Date:  2017-08-14       Impact factor: 17.745

4.  Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area.

Authors:  Yan He; Susana Campino; Ernest Diez Benavente; David C Warhurst; Khalid B Beshir; Inke Lubis; Ana Rita Gomes; Jun Feng; Wang Jiazhi; Xiaodong Sun; Fang Huang; Lin-Hua Tang; Colin J Sutherland; Taane G Clark
Journal:  PLoS One       Date:  2019-03-18       Impact factor: 3.240

5.  Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children.

Authors:  Adoke Yeka; Erika Wallender; Ronald Mulebeke; Afizi Kibuuka; Ruth Kigozi; Agaba Bosco; Paul Kyambadde; Jimmy Opigo; Simeon Kalyesubula; Joseph Senzoga; Joanna Vinden; Melissa Conrad; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2019-03-15       Impact factor: 5.226

6.  Evolution of Antimalarial Drug Resistance Markers in the Reservoir of Plasmodium falciparum Infections in the Upper East Region of Ghana.

Authors:  Charles A Narh; Anita Ghansah; Michael F Duffy; Shazia Ruybal-Pesántez; Christiana O Onwona; Abraham R Oduro; Kwadwo A Koram; Karen P Day; Kathryn E Tiedje
Journal:  J Infect Dis       Date:  2020-10-13       Impact factor: 5.226

7.  The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda.

Authors:  Melissa D Conrad; Sam L Nsobya; Philip J Rosenthal
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8.  Changing Antimalarial Drug Sensitivities in Uganda.

Authors:  Stephanie A Rasmussen; Frida G Ceja; Melissa D Conrad; Patrick K Tumwebaze; Oswald Byaruhanga; Thomas Katairo; Samuel L Nsobya; Philip J Rosenthal; Roland A Cooper
Journal:  Antimicrob Agents Chemother       Date:  2017-11-22       Impact factor: 5.191

Review 9.  Drug resistance in Plasmodium.

Authors:  Kasturi Haldar; Souvik Bhattacharjee; Innocent Safeukui
Journal:  Nat Rev Microbiol       Date:  2018-01-22       Impact factor: 60.633

10.  Multiple Novel Mutations in Plasmodium falciparum Chloroquine Resistance Transporter Gene during Implementation of Artemisinin Combination Therapy in Thailand.

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Journal:  Am J Trop Med Hyg       Date:  2018-10       Impact factor: 2.345
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