| Literature DB >> 28038349 |
Juan Mangas-Sanchez1, Scott P France1, Sarah L Montgomery1, Godwin A Aleku1, Henry Man2, Mahima Sharma2, Jeremy I Ramsden1, Gideon Grogan2, Nicholas J Turner3.
Abstract
Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.Entities:
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Year: 2016 PMID： 28038349 DOI： 10.1016/j.cbpa.2016.11.022
Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822