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Literature DB >> 2803504

Bacterial toxins as probes for the T-cell antigen receptor.

Abstract

A variety of microorganisms produce substances with suppressive or stimulating effects on cells of the immune system; these products also influence the pathogenesis of these diseases. A number of microorganisms produce toxins with mitogenic potential for T cells of many species, and in this article Bernhard Fleischer discusses how these toxins may be useful tools to improve understanding of the structure and function of the T-cell antigen receptor.

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Year: 1989 PMID： 2803504 DOI： 10.1016/0167-5699(89)90137-0

Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699

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Cited

11 in total

1. Distinct T-cell receptor V beta gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein.

Authors: M A Tomai; P M Schlievert; M Kotb
Journal: Infect Immun Date: 1992-02 Impact factor: 3.441

Review 2. T lymphocyte-stimulating microbial toxins as "superantigens".

Authors: B Fleischer
Journal: Med Microbiol Immunol Date: 1991 Impact factor: 3.402

Review 3. Microbial "superantigens".

Authors: M L Misfeldt
Journal: Infect Immun Date: 1990-08 Impact factor: 3.441

4. Mechanism of stimulation of T cells by Streptococcus pyogenes: isolation of a major mitogenic factor, cytoplasmic membrane-associated protein.

Authors: T Itoh; H Satoh; N Isono; H Rikiishi; K Kumagai
Journal: Infect Immun Date: 1992-08 Impact factor: 3.441

10. A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.

Authors: D Kabelitz; A Bender; S Schondelmaier; B Schoel; S H Kaufmann
Journal: J Exp Med Date: 1990-03-01 Impact factor: 14.307

Bacterial toxins as probes for the T-cell antigen receptor.

1. Distinct T-cell receptor V beta gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein.

Review 2. T lymphocyte-stimulating microbial toxins as "superantigens".

Review 3. Microbial "superantigens".

4. Mechanism of stimulation of T cells by Streptococcus pyogenes: isolation of a major mitogenic factor, cytoplasmic membrane-associated protein.

5. Separation of T-cell-stimulating activity from streptococcal M protein.

6. Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen.

7. In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor.

8. Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity.

9. CD8+ T cells respond clonally to Mls-1a-encoded determinants.

10. A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.