Literature DB >> 1549069

Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen.

B Fleischer1, C J Bailey.   

Abstract

The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as "superantigens". Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.

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Year:  1992        PMID： 1549069     DOI： 10.1007/bf00191548

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  16 in total

1.  Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

Authors:  Y W Choi; B Kotzin; L Herron; J Callahan; P Marrack; J Kappler
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  An evolutionary conserved mechanism of T cell activation by microbial toxins. Evidence for different affinities of T cell receptor-toxin interaction.

Authors:  B Fleischer; R Gerardy-Schahn; B Metzroth; S Carrel; D Gerlach; W Köhler
Journal:  J Immunol       Date:  1991-01-01       Impact factor: 5.422

3.  A comparative study of two serotypes of epidermolytic toxin from Staphylococcus aureus.

Authors:  C J Bailey; J de Azavedo; J P Arbuthnott
Journal:  Biochim Biophys Acta       Date:  1980-07-24

4.  Nucleotide sequence of the epidermolytic toxin A gene of Staphylococcus aureus.

Authors:  P W O'Toole; T J Foster
Journal:  J Bacteriol       Date:  1987-09       Impact factor: 3.490

Review 5.  The staphylococcal enterotoxins and their relatives.

Authors:  P Marrack; J Kappler
Journal:  Science       Date:  1990-05-11       Impact factor: 47.728

6.  A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus.

Authors:  Y Choi; J W Kappler; P Marrack
Journal:  Nature       Date:  1991-03-21       Impact factor: 49.962

7.  Mitogenic activity of staphylococcal exfoliative toxin.

Authors:  B A Morlock; L Spero; A D Johnson
Journal:  Infect Immun       Date:  1980-11       Impact factor: 3.441

8.  Molecular cloning and expression of the epidermolytic toxin A gene of Staphylococcus aureus.

Authors:  P W O'Toole; T J Foster
Journal:  Microb Pathog       Date:  1986-12       Impact factor: 3.738

9.  Superantigenicity of streptococcal M protein.

Authors:  M Tomai; M Kotb; G Majumdar; E H Beachey
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307

10.  HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.

Authors:  A Herman; G Croteau; R P Sekaly; J Kappler; P Marrack
Journal:  J Exp Med       Date:  1990-09-01       Impact factor: 14.307
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  11 in total

1.  Structural similarities and differences in Staphylococcus aureus exfoliative toxins A and B as revealed by their crystal structures.

Authors:  A C Papageorgiou; L R Plano; C M Collins; K R Acharya
Journal:  Protein Sci       Date:  2000-03       Impact factor: 6.725

2.  Recombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens.

Authors:  L R Plano; D M Gutman; M Woischnik; C M Collins
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441

3.  Concomitant loss of conformation and superantigenic activity of staphylococcal enterotoxin B deletion mutant proteins.

Authors:  B Metzroth; T Marx; M Linnig; B Fleischer
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441

4.  Langerhans' cell depletion by staphylococcal superantigens.

Authors:  S Pickard; G Shankar; K Burnham
Journal:  Immunology       Date:  1994-12       Impact factor: 7.397

Review 5.  Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome.

Authors:  S Ladhani; C L Joannou; D P Lochrie; R W Evans; S M Poston
Journal:  Clin Microbiol Rev       Date:  1999-04       Impact factor: 26.132

6.  Separation of T-cell-stimulating activity from streptococcal M protein.

Authors:  B Fleischer; K H Schmidt; D Gerlach; W Köhler
Journal:  Infect Immun       Date:  1992-05       Impact factor: 3.441

Review 7.  The epidermolytic (exfoliative) toxins of Staphylococcus aureus.

Authors:  C J Bailey; B P Lockhart; M B Redpath; T P Smith
Journal:  Med Microbiol Immunol       Date:  1995-08       Impact factor: 3.402

8.  A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C.

Authors:  J A Mollick; G G Miller; J M Musser; R G Cook; D Grossman; R R Rich
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

Review 9.  Superantigens and pseudosuperantigens of gram-positive cocci.

Authors:  B Fleischer; D Gerlach; A Fuhrmann; K H Schmidt
Journal:  Med Microbiol Immunol       Date:  1995-05       Impact factor: 3.402

Review 10.  Exfoliative toxins of Staphylococcus aureus.

Authors:  Michal Bukowski; Benedykt Wladyka; Grzegorz Dubin
Journal:  Toxins (Basel)       Date:  2010-05-25       Impact factor: 4.546
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