Roy Poblete1, Ling Zheng2, Ranjita Raghavan2, Steven Cen2, Arun Amar3, Nerses Sanossian2, William Mack3, May Kim-Tenser2. 1. Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. Electronic address: roy.poblete@med.usc.edu. 2. Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. 3. Department of Neurological Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Abstract
BACKGROUND: Patients with aneurysmal subarachnoid hemorrhage (aSAH) are susceptible to various medical complications, including ventriculostomy-associated infections (VAIs) in those who undergo external ventricular drain (EVD) placement. Many preventative strategies for VAIs have been used during the last 20 years, but their overall effect is unknown. Using the Nationwide (National) Inpatient Sample, we examined trends in VAI rates and mortality during a recent 12-year period in the aSAH population. METHODS: In this retrospective analysis, data from the Nationwide Inpatient Sample was obtained from January 1, 2000, through December 31, 2011, using International Classification of Diseases, 9th Revision, Clinical Modification codes. After adjustment for age, sex, race, and subarachnoid severity, annual estimated event rates of VAI, in-hospital mortality, and hospital length of stay were calculated. Changes in these parameters during the study period were analyzed. RESULTS: From years 2000 through 2011, there were 116,013 aSAH admissions, with EVD placement in 38,163 (32.9%) cases. In patients who underwent EVD placement, the mean annual rate of VAI was 7.3 per 100 patients, with no change during the 12-year period (absolute risk reduction per year of -0.05%, 95% confidence interval -0.22, 0.13). The mean mortality rate in this population was 19.8 per 100 patients, significantly declining over the study period (absolute risk reduction per year of -0.55%, 95% confidence interval -0.82, -0.29). CONCLUSIONS: Despite numerous VAI-preventative strategies, the national VAI rate in aSAH patients has not changed; however, a reduction in mortality is suggested. Further studies are needed to determine how best to reduce VAIs, and to identify factors influencing observed trends in VAI and mortality.
BACKGROUND:Patients with aneurysmal subarachnoid hemorrhage (aSAH) are susceptible to various medical complications, including ventriculostomy-associated infections (VAIs) in those who undergo external ventricular drain (EVD) placement. Many preventative strategies for VAIs have been used during the last 20 years, but their overall effect is unknown. Using the Nationwide (National) Inpatient Sample, we examined trends in VAI rates and mortality during a recent 12-year period in the aSAH population. METHODS: In this retrospective analysis, data from the Nationwide Inpatient Sample was obtained from January 1, 2000, through December 31, 2011, using International Classification of Diseases, 9th Revision, Clinical Modification codes. After adjustment for age, sex, race, and subarachnoid severity, annual estimated event rates of VAI, in-hospital mortality, and hospital length of stay were calculated. Changes in these parameters during the study period were analyzed. RESULTS: From years 2000 through 2011, there were 116,013 aSAH admissions, with EVD placement in 38,163 (32.9%) cases. In patients who underwent EVD placement, the mean annual rate of VAI was 7.3 per 100 patients, with no change during the 12-year period (absolute risk reduction per year of -0.05%, 95% confidence interval -0.22, 0.13). The mean mortality rate in this population was 19.8 per 100 patients, significantly declining over the study period (absolute risk reduction per year of -0.55%, 95% confidence interval -0.82, -0.29). CONCLUSIONS: Despite numerous VAI-preventative strategies, the national VAI rate in aSAH patients has not changed; however, a reduction in mortality is suggested. Further studies are needed to determine how best to reduce VAIs, and to identify factors influencing observed trends in VAI and mortality.
Authors: Bujung Hong; Anani Apedjinou; Hans E Heissler; Hind Chaib; Josef M Lang; Shadi Al-Afif; Joachim K Krauss Journal: Acta Neurochir (Wien) Date: 2021-01-11 Impact factor: 2.216
Authors: Roy A Poblete; Marcela Arenas; Nerses Sanossian; Young-Kwon Hong; William D Freeman; Patrick D Lyden; Stan G Louie Journal: Am J Transl Res Date: 2022-03-15 Impact factor: 4.060