| Literature DB >> 28025886 |
Wei-Wei Dong1, Fang-Ling Xuan1, Fei-Liang Zhong1, Jun Jiang1, Songquan Wu1, Donghao Li1, Lin-Hu Quan1.
Abstract
Following oral intake of Panax ginseng, major ginsenosides are metabolized to deglycosylated ginsenosides by gut microbiota before absorption into the blood. As the composition of gut microbiota varies between individuals, metabolic activities are significantly different. We selected 6 rats with low efficiency metabolism (LEM) and 6 rats with high efficiency metabolism (HEM) from 60 rats following oral administration of Panax ginseng extract, and analyzed their gut microbiota composition using Illumina HiSeq sequencing of the 16S rRNA gene. The components of gut microbiota between the LEM and HEM groups were significantly different. Between the 2 groups, S24-7, Alcaligenaceae, and Erysipelotrichaceae occupied most OTUs of the HEM group, which was notably higher than the LEM group. Furthermore, we isolated Bifidobacterium animalis GM1 that could convert the ginsenoside Rb1 to Rd. The result implies that these specific intestinal bacteria may dominate the metabolism of Panax ginseng.Entities:
Keywords: LC-MS/MS; Panax ginseng; ginsenoside; metabolism; rats gut microbiota
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Year: 2017 PMID： 28025886 DOI： 10.1021/acs.jafc.6b04848
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279