Ilse I M Tromp1, Oscar H Franco2, Edith H van den Hooven2, Annemieke C Heijboer3, Vincent W V Jaddoe4, Liesbeth Duijts5, Johan C de Jongste6, Henriëtte A Moll7, Jessica C Kiefte-de Jong8. 1. From the Generation R Study Group, The Netherlands; Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands. 2. Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands. 3. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands. 4. From the Generation R Study Group, The Netherlands; Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands; Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands. 5. Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands; Division of Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands; Division of Neonatology, Erasmus University, Rotterdam, The Netherlands. 6. Division of Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands. 7. Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands. 8. Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands; Global Public Health, Leiden University College, The Hague, The Netherlands; Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands. Electronic address: j.c.kiefte-dejong@erasmusmc.nl.
Abstract
BACKGROUND & AIMS: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. METHODS: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires. RESULTS: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95% CI: 1.34-4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: -1.26; 95% CI: -1.66 to -0.85) (ß: -0.75; 95% CI: -1.08 to -0.42), and increased risks of eczema (OR: 1.65; 95% CI: 1.13-2.41) (OR: 1.44; 95% CI: 1.06-1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95% CI: 0.38-0.94). CONCLUSIONS: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.
BACKGROUND & AIMS: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. METHODS: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires. RESULTS: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95% CI: 1.34-4.80). In addition, deficient and insufficient25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: -1.26; 95% CI: -1.66 to -0.85) (ß: -0.75; 95% CI: -1.08 to -0.42), and increased risks of eczema (OR: 1.65; 95% CI: 1.13-2.41) (OR: 1.44; 95% CI: 1.06-1.95). Insufficient25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95% CI: 0.38-0.94). CONCLUSIONS: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638
Authors: N Oosterom; N F Dirks; S G Heil; R de Jonge; W J E Tissing; R Pieters; M M van den Heuvel-Eibrink; A C Heijboer; S M F Pluijm Journal: Support Care Cancer Date: 2018-06-19 Impact factor: 3.603
Authors: Sara M Mensink-Bout; Evelien R van Meel; Johan C de Jongste; Trudy Voortman; Irwin K Reiss; Nicolette W De Jong; Vincent W V Jaddoe; Liesbeth Duijts Journal: Clin Exp Allergy Date: 2019-04-29 Impact factor: 5.018