Literature DB >> 2801341

The effect of indomethacin on cartilage breakdown.

F M Desa1, C L Chander, A R Moore, D W Howat, D G Corry, D A Willoughby.   

Abstract

The effects of recombinant interleukin-1 alpha (rIL-1 alpha) and indomethacin on the glycosaminoglycan (GAG) content of rat femoral head cartilage (FHC) were studied in vitro. Net GAG loss was observed from cartilage cultured in the presence of indomethacin plus rIL-1 alpha. Indomethacin and rIL-1 alpha alone caused no net loss of GAG from cartilage unless the cartilage was cultured in the presence of fibroblasts.

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Year:  1989        PMID: 2801341     DOI: 10.1007/bf01972859

Source DB:  PubMed          Journal:  Agents Actions        ISSN: 0065-4299


  7 in total

1.  Indomethacin and cartilage breakdown.

Authors:  F M Desa; C L Chander; D W Howat; A R Moore; D A Willoughby
Journal:  J Pharm Pharmacol       Date:  1988-09       Impact factor: 3.765

2.  Macrophage-fibroblast interactions in collagenase production and cartilage degradation.

Authors:  G Huybrechts-Godin; P Hauser; G Vaes
Journal:  Biochem J       Date:  1979-12-15       Impact factor: 3.857

3.  Drug effects on a novel model of connective tissue breakdown.

Authors:  F B De Brito; M J Holmes; S L Carney; D A Willoughby
Journal:  Agents Actions       Date:  1987-08

4.  Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.

Authors:  H E Jasin; J T Dingle
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

5.  A radioimmunoassay for 6-keto-prostaglandin F1alpha.

Authors:  J A Salmon
Journal:  Prostaglandins       Date:  1978-03

6.  Studies into the influence of carrageenan-induced inflammation on articular cartilage degradation using implantation into air pouches.

Authors:  A D Sedgwick; A R Moore; A Y Al-Duaij; J C Edwards; D A Willoughby
Journal:  Br J Exp Pathol       Date:  1985-08

7.  A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures.

Authors:  R W Farndale; C A Sayers; A J Barrett
Journal:  Connect Tissue Res       Date:  1982       Impact factor: 3.417

  7 in total
  1 in total

1.  Professor Derek Albert Willoughby (1930-2004).

Authors:  K D Rainsford
Journal:  Inflammopharmacology       Date:  2005       Impact factor: 4.473

  1 in total

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