Ulrike I Attenberger1, Melissa M Ong1, Nils Rathmann1, Fabian Doyon2, Peter Kienle2, Ralf-Dieter Hofheinz3, Lothar R Pilz4, Dietmar J Dinter1, Stefan O Schoenberg1, Daniel Hausmann5. 1. Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 2. Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 3. Department of Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 4. Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 5. Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany daniel.hausmann@medma.uni-heidelberg.de.
Abstract
AIM: To assess whether multiparametric MRI (mMRI) can serve as a tool for evaluating response to chemoradiation therapy (CRT) in advanced-stage rectal cancer. PATIENTS AND METHODS: Twenty-one patients underwent a mMRI protocol at 3T before and after CRT. Two experienced radiologists evaluated the MRI measurements and inter-reader correlation was assessed. Changes in functional parameters in relation to regression, as well as pT stage were analyzed. The perfusion parameters plasma flow (PF) and mean transit time (MTT) were calculated offline using the established UMM Perfusion tool. RESULTS: Apparent diffusion coefficient values were significantly different among the different tumor RGs before CRT (p=0.041). Changes of dynamic contrast enhanced (DCE) MRI values did not reflect treatment response (PF: p=0.5; MTT: p=0.74). CONCLUSION: The results of our study population indicate that a high initial apparent diffusion coefficient value may be predictive of response to therapy following CRT. Copyright
AIM: To assess whether multiparametric MRI (mMRI) can serve as a tool for evaluating response to chemoradiation therapy (CRT) in advanced-stage rectal cancer. PATIENTS AND METHODS: Twenty-one patients underwent a mMRI protocol at 3T before and after CRT. Two experienced radiologists evaluated the MRI measurements and inter-reader correlation was assessed. Changes in functional parameters in relation to regression, as well as pT stage were analyzed. The perfusion parameters plasma flow (PF) and mean transit time (MTT) were calculated offline using the established UMM Perfusion tool. RESULTS: Apparent diffusion coefficient values were significantly different among the different tumor RGs before CRT (p=0.041). Changes of dynamic contrast enhanced (DCE) MRI values did not reflect treatment response (PF: p=0.5; MTT: p=0.74). CONCLUSION: The results of our study population indicate that a high initial apparent diffusion coefficient value may be predictive of response to therapy following CRT. Copyright
Authors: Ruben S A Goedegebuure; Leonie K de Klerk; Adam J Bass; Sarah Derks; Victor L J L Thijssen Journal: Front Immunol Date: 2019-01-14 Impact factor: 7.561
Authors: Barbara D Wichtmann; Steffen Albert; Wenzhao Zhao; Angelika Maurer; Claus Rödel; Ralf-Dieter Hofheinz; Jürgen Hesser; Frank G Zöllner; Ulrike I Attenberger Journal: Diagnostics (Basel) Date: 2022-06-30