PURPOSE: To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS: This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol. Complete screening procedures had involved 66 eyes of 33 patients afferent to the Center for Retinitis Pigmentosa of the Veneto Region. RESULTS: Preoperative OCT examination resulted in the exclusion of 8 eyes in 4 patients with bilateral posterior staphyloma diagnosing unexpected staphylomatous macular patterns in 2 patients with RP and no sign of pathologic myopia. Postoperative OCT study of Argus II proximity to retinal surface indicated a plausible correlation between electrode-retina distance and perceptual threshold in 2 of our 3 patients. In particular, during the first 6 months of follow-up, the patient with the closest contact between device and macula showed a continuous vision-related improvement in the performance of several real-life tasks. CONCLUSIONS: The present findings illustrate the modalities by which each different OCT examination is an essential tool to optimize safety and efficacy profiles during Argus II protocol. Optical coherence tomography will be crucial for future investigative approaches on patient selection criteria and next-generation implant design.
PURPOSE: To report a real-life experience with the Argus II retinal prosthesis system in blindpatients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS: This hospital-based case series included 3 blindpatients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol. Complete screening procedures had involved 66 eyes of 33 patients afferent to the Center for Retinitis Pigmentosa of the Veneto Region. RESULTS: Preoperative OCT examination resulted in the exclusion of 8 eyes in 4 patients with bilateral posterior staphyloma diagnosing unexpected staphylomatous macular patterns in 2 patients with RP and no sign of pathologic myopia. Postoperative OCT study of Argus II proximity to retinal surface indicated a plausible correlation between electrode-retina distance and perceptual threshold in 2 of our 3 patients. In particular, during the first 6 months of follow-up, the patient with the closest contact between device and macula showed a continuous vision-related improvement in the performance of several real-life tasks. CONCLUSIONS: The present findings illustrate the modalities by which each different OCT examination is an essential tool to optimize safety and efficacy profiles during Argus II protocol. Optical coherence tomography will be crucial for future investigative approaches on patient selection criteria and next-generation implant design.
Authors: Ninel Z Gregori; Natalia F Callaway; Catherine Hoeppner; Alex Yuan; Aleksandra Rachitskaya; William Feuer; Hossein Ameri; J Fernando Arevalo; Albert J Augustin; David G Birch; Gislin Dagnelie; Salvatore Grisanti; Janet L Davis; Paul Hahn; James T Handa; Allen C Ho; Suber S Huang; Mark S Humayun; Raymond Iezzi; K Thiran Jayasundera; Gregg T Kokame; Byron L Lam; Jennifer I Lim; Naresh Mandava; Sandra R Montezuma; Lisa Olmos de Koo; Peter Szurman; Lejla Vajzovic; Peter Wiedemann; James Weiland; Jiong Yan; David N Zacks Journal: Am J Ophthalmol Date: 2018-06-27 Impact factor: 5.258
Authors: Carla J Abbott; Elizabeth K Baglin; Maria Kolic; Myra B McGuinness; Samuel A Titchener; Kiera A Young; Jonathan Yeoh; Chi D Luu; Lauren N Ayton; Matthew A Petoe; Penelope J Allen Journal: Transl Vis Sci Technol Date: 2022-09-01 Impact factor: 3.048