| Literature DB >> 28006694 |
Laurien M Buffart1, Joeri Kalter2, Maike G Sweegers3, Kerry S Courneya4, Robert U Newton5, Neil K Aaronson6, Paul B Jacobsen7, Anne M May8, Daniel A Galvão9, Mai J Chinapaw10, Karen Steindorf11, Melinda L Irwin12, Martijn M Stuiver13, Sandi Hayes14, Kathleen A Griffith15, Alejandro Lucia16, Ilse Mesters17, Ellen van Weert18, Hans Knoop19, Martine M Goedendorp20, Nanette Mutrie21, Amanda J Daley22, Alex McConnachie23, Martin Bohus24, Lene Thorsen25, Karl-Heinz Schulz26, Camille E Short27, Erica L James28, Ron C Plotnikoff29, Gill Arbane30, Martina E Schmidt31, Karin Potthoff32, Marc van Beurden33, Hester S Oldenburg34, Gabe S Sonke35, Wim H van Harten36, Rachel Garrod37, Kathryn H Schmitz38, Kerri M Winters-Stone39, Miranda J Velthuis40, Dennis R Taaffe41, Willem van Mechelen42, Marie-José Kersten43, Frans Nollet44, Jennifer Wenzel45, Joachim Wiskemann46, Irma M Verdonck-de Leeuw47, Johannes Brug48.
Abstract
This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications. Principle investigators of all 69 eligible trials were requested to share IPD from their study. IPD from 34 randomised controlled trials (n=4519 patients) that evaluated the effects of exercise compared to a usual care, wait-list or attention control group on QoL and PF in adult patients with cancer were retrieved and pooled. Linear mixed-effect models were used to evaluate the effects of the exercise on post-intervention outcome values (z-score) adjusting for baseline values. Moderator effects were studies by testing interactions. Exercise significantly improved QoL (β=0.15, 95%CI=0.10;0.20) and PF (β=0.18, 95%CI=0.13;0.23). The effects were not moderated by demographic, clinical or exercise characteristics. Effects on QoL (βdifference_in_effect=0.13, 95%CI=0.03;0.22) and PF (βdifference_in_effect=0.10, 95%CI=0.01;0.20) were significantly larger for supervised than unsupervised interventions. In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment. Although effect sizes are small, there is consistent empirical evidence to support implementation of exercise as part of cancer care.Entities:
Keywords: Exercise; Individual patient data meta-analysis; Neoplasm; Physical function; Quality of life
Mesh：
Year: 2016 PMID： 28006694 DOI： 10.1016/j.ctrv.2016.11.010
Source DB: PubMed Journal: Cancer Treat Rev ISSN： 0305-7372 Impact factor: 12.111