Literature DB >> 1012711

A cybernetic approach to the origin of the genetic coding mechanism. I. Methodological principles.

V A Ratner, A G Batchinsky.   

Abstract

It is postulated that some quasi-deterministic code features (universality, connectedness, systematic degeneracy, symmetry, regularity and so on) resulted from unique (and therefore universal) relization of a stochastic evolutionary process. The evolution of real genetic systems should satisfy the principle of succession; that is, loss of a feature that is necessary for a genetic system means death to its carrier. The hypothesis of unique key coincidence is proposed which indicates the mechanisms of arising of the primary correspondence between the linear structures of polynucleotides and polypeptides. If the collinear coincidence was to appear in the key positions of pra-protein with, at least, some of the primitive properties of the pra-amino-acyl-t-RNA-synthetase required for the accelerated recognition of the key positions of pra-template, the positive feed-back mechanism in the system would be most short-circuited so that the repetitive reproduction of pra-synthetase would be much accelerated.

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Year:  1976        PMID: 1012711     DOI: 10.1007/BF00926939

Source DB:  PubMed          Journal:  Orig Life        ISSN: 0302-1688


  1 in total

1.  The origin of the genetic code.

Authors:  B R Thomas
Journal:  Biochem Biophys Res Commun       Date:  1970-09-30       Impact factor: 3.575

  1 in total
  5 in total

1.  A cybernetic approach to the origin of the genetic coding mechanism. II. Formation of the code series.

Authors:  A G Batchinsky; V A Ratner
Journal:  Orig Life       Date:  1976-08

2.  Origin of the genetic code: a testable hypothesis based on tRNA structure, sequence, and kinetic proofreading.

Authors:  J J Hopfield
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

3.  Are there structural analogies between amino acids and nucleic acids?

Authors:  L B Hendry; E D Bransome; M Petersheim
Journal:  Orig Life       Date:  1981-09

4.  First approximation of a stereochemical rationale for the genetic code based on the topography and physicochemical properties of "cavities" constructed from models of DNA.

Authors:  L B Hendry; E D Bransome; M S Hutson; L K Campbell
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

5.  Ambiguity and the evolution of the genetic code.

Authors:  R R Kocherlakota; N D Acland
Journal:  Orig Life       Date:  1982-03
  5 in total

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