Literature DB >> 27990091

Novel applications of COX-2 inhibitors, metformin, and statins for the primary chemoprevention of breast cancer.

Darren Micallef1, Sarah Micallef1, Pierre Schembri-Wismayer1, Jean Calleja-Agius1.   

Abstract

Recent evidence shows that commonly prescribed drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), metformin, and statins, may have beneficial roles in the primary chemoprevention of breast cancer. Therefore, these drugs could potentially be used in addition to the hormonal drugs currently used for this purpose (namely, selective estrogen receptor modulators and aromatase inhibitors) due to their alternative mechanisms of action.

Entities:  

Keywords:  Chemoprophylaxis; anti-inflammatory agents; breast neoplasms; hydroxymethylglutaryl-CoA reductase inhibitors; metformin; non-steroidal

Year:  2016        PMID： 27990091      PMCID： PMC5147761          DOI： 10.5152/jtgga.2016.15200

Source DB:  PubMed          Journal:  J Turk Ger Gynecol Assoc        ISSN： 1309-0380


  64 in total

1.  Statins and Breast Cancer: Future Directions in Chemoprevention.

Authors:  Cesar A Santa-Maria; Vered Stearns
Journal:  Curr Breast Cancer Rep       Date:  2013-09-01

Review 2.  COX-2 inhibitors and cardiovascular risk.

Authors:  Colin D Funk; Garret A FitzGerald
Journal:  J Cardiovasc Pharmacol       Date:  2007-11       Impact factor: 3.105

3.  Androgens and estrogens in postmenopausal insulin-treated diabetic women.

Authors:  H Nyholm; H Djursing; C Hagen; T Agner; P Bennett; B Svenstrup
Journal:  J Clin Endocrinol Metab       Date:  1989-11       Impact factor: 5.958

4.  3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: a nested case-control study.

Authors:  L Blais; A Desgagné; J LeLorier
Journal:  Arch Intern Med       Date:  2000 Aug 14-28

5.  Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies.

Authors:  T Key; P Appleby; I Barnes; G Reeves
Journal:  J Natl Cancer Inst       Date:  2002-04-17       Impact factor: 13.506

Review 6.  Therapy insight: Potential of statins for cancer chemoprevention and therapy.

Authors:  Matthew S Katz
Journal:  Nat Clin Pract Oncol       Date:  2005-02

7.  Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women.

Authors:  Kaoru Hirose; Tatsuya Toyama; Hiroji Iwata; Toshiro Takezaki; Nobuyuki Hamajima; Kazuo Tajima
Journal:  Asian Pac J Cancer Prev       Date:  2003 Jul-Sep

Review 8.  Metformin: a review of its pharmacological properties and therapeutic use.

Authors:  L S Hermann
Journal:  Diabete Metab       Date:  1979-09

9.  Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.

Authors:  Sao Jiralerspong; Shana L Palla; Sharon H Giordano; Funda Meric-Bernstam; Cornelia Liedtke; Chad M Barnett; Limin Hsu; Mien-Chie Hung; Gabriel N Hortobagyi; Ana M Gonzalez-Angulo
Journal:  J Clin Oncol       Date:  2009-06-01       Impact factor: 44.544

10.  Lipid-lowering drug use and breast cancer in older women: a prospective study.

Authors:  Jane A Cauley; Joseph M Zmuda; Li-Yung Lui; Teresa A Hillier; Roberta B Ness; Katie L Stone; Steven R Cummings; Douglas C Bauer
Journal:  J Womens Health (Larchmt)       Date:  2003-10       Impact factor: 2.681
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  5 in total

Review 1.  Metformin and Breast Cancer: Molecular Targets.

Authors:  J Faria; G Negalha; A Azevedo; F Martel
Journal:  J Mammary Gland Biol Neoplasia       Date:  2019-03-22       Impact factor: 2.673

2.  Preclinical meritorious anticancer effects of Metformin against breast cancer: An In vivo trial.

Authors:  Fatima Rizvi; Lubna Shaukat; Arfa Azhar; Alia Jafri; Unum Aslam; Hafiz Imran-Ul-Haq
Journal:  J Taibah Univ Med Sci       Date:  2021-03-17

3.  Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities.

Authors:  Barbara Nuvoli; Barbara Antoniani; Roberta Libener; Antonio Maconi; Andrea Sacconi; Mariantonia Carosi; Rossella Galati
Journal:  J Exp Clin Cancer Res       Date:  2021-08-17

Review 4.  Risk Reduction Strategies in Breast Cancer Prevention.

Authors:  Mauricio Costa; Paula Saldanha
Journal:  Eur J Breast Health       Date:  2017-07-01

5.  Metformin in the management of fibrocystic breast disease: a placebo-controlled randomized clinical trial.

Authors:  Sadaf Alipour; Hadith Rastad; Azin Saberi; Firoozeh Faiz; Arezoo Maleki-Hajiagha; Mahboubeh Abedi
Journal:  Daru       Date:  2021-10-31       Impact factor: 3.117
  5 in total

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