| Literature DB >> 27989323 |
Ari V Ahola-Olli1, Peter Würtz2, Aki S Havulinna3, Kristiina Aalto4, Niina Pitkänen5, Terho Lehtimäki6, Mika Kähönen7, Leo-Pekka Lyytikäinen6, Emma Raitoharju6, Ilkka Seppälä6, Antti-Pekka Sarin8, Samuli Ripatti9, Aarne Palotie10, Markus Perola8, Jorma S Viikari11, Sirpa Jalkanen4, Mikael Maksimow4, Veikko Salomaa3, Marko Salmi4, Johannes Kettunen12, Olli T Raitakari13.
Abstract
Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 × 10-9) for one or more cytokines. Fifteen of the associated variants had expression quantitative trait loci in whole blood. We provide genetic instruments to clarify the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases. We further link inflammatory markers with variants previously associated with autoimmune diseases such as Crohn disease, multiple sclerosis, and ulcerative colitis and hereby elucidate the molecular mechanisms underpinning these diseases and suggest potential drug targets.Entities:
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Year: 2016 PMID： 27989323 PMCID： PMC5223028 DOI： 10.1016/j.ajhg.2016.11.007
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025