Literature DB >> 27988096

Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target.

Anyango D Kamina1, Noreen Williams2.   

Abstract

In Liu et al., the authors present a 2.5-Å structure of the Trypanosoma cruzi 60S ribosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rRNA). Based on this study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug targets.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  rRNA processing; ribosome assembly; ribosome structure.; trypanosomatids

Mesh：

Substances：

Year:  2016        PMID： 27988096      PMCID： PMC5376504          DOI： 10.1016/j.pt.2016.12.003

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  9 in total

1.  UCSF Chimera--a visualization system for exploratory research and analysis.

Authors:  Eric F Pettersen; Thomas D Goddard; Conrad C Huang; Gregory S Couch; Daniel M Greenblatt; Elaine C Meng; Thomas E Ferrin
Journal:  J Comput Chem       Date:  2004-10       Impact factor: 3.376

2.  A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification.

Authors:  Xue-Hai Liang; Shai Uliel; Avraham Hury; Sarit Barth; Tirza Doniger; Ron Unger; Shulamit Michaeli
Journal:  RNA       Date:  2005-05       Impact factor: 4.942

Review 3.  Ribosome-targeting antibiotics and mechanisms of bacterial resistance.

Authors:  Daniel N Wilson
Journal:  Nat Rev Microbiol       Date:  2014-01       Impact factor: 60.633

4.  A major tyrosine-phosphorylated protein of Trypanosoma brucei is a nucleolar RNA-binding protein.

Authors:  A Das; G C Peterson; S B Kanner; U Frevert; M Parsons
Journal:  J Biol Chem       Date:  1996-06-28       Impact factor: 5.157

5.  Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.

Authors:  Zheng Liu; Cristina Gutierrez-Vargas; Jia Wei; Robert A Grassucci; Madhumitha Ramesh; Noel Espina; Ming Sun; Beril Tutuncuoglu; Susan Madison-Antenucci; John L Woolford; Liang Tong; Joachim Frank
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-10       Impact factor: 11.205

6.  Two trypanosome-specific proteins are essential factors for 5S rRNA abundance and ribosomal assembly in Trypanosoma brucei.

Authors:  Kristina M Hellman; Martin Ciganda; Silvia V Brown; Jinlei Li; William Ruyechan; Noreen Williams
Journal:  Eukaryot Cell       Date:  2007-08-22

7.  2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.

Authors:  Moran Shalev-Benami; Yan Zhang; Donna Matzov; Yehuda Halfon; Arie Zackay; Haim Rozenberg; Ella Zimmerman; Anat Bashan; Charles L Jaffe; Ada Yonath; Georgios Skiniotis
Journal:  Cell Rep       Date:  2016-06-30       Impact factor: 9.423

8.  A hierarchical model for assembly of eukaryotic 60S ribosomal subunit domains.

Authors:  Michael Gamalinda; Uli Ohmayer; Jelena Jakovljevic; Beril Kumcuoglu; Joshua Woolford; Bertrade Mbom; Lawrence Lin; John L Woolford
Journal:  Genes Dev       Date:  2014-01-15       Impact factor: 11.361

9.  High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome.

Authors:  Yaser Hashem; Amedee des Georges; Jie Fu; Sarah N Buss; Fabrice Jossinet; Amy Jobe; Qin Zhang; Hstau Y Liao; Robert A Grassucci; Chandrajit Bajaj; Eric Westhof; Susan Madison-Antenucci; Joachim Frank
Journal:  Nature       Date:  2013-02-10       Impact factor: 49.962
  9 in total
  1 in total

1.  Experimental evolution links post-transcriptional regulation to Leishmania fitness gain.

Authors:  Laura Piel; K Shanmugha Rajan; Giovanni Bussotti; Hugo Varet; Rachel Legendre; Caroline Proux; Thibaut Douché; Quentin Giai-Gianetto; Thibault Chaze; Thomas Cokelaer; Barbora Vojtkova; Nadav Gordon-Bar; Tirza Doniger; Smadar Cohen-Chalamish; Praveenkumar Rengaraj; Céline Besse; Anne Boland; Jovana Sadlova; Jean-François Deleuze; Mariette Matondo; Ron Unger; Petr Volf; Shulamit Michaeli; Pascale Pescher; Gerald F Späth
Journal:  PLoS Pathog       Date:  2022-03-16       Impact factor: 6.823
  1 in total

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