Xiaoqing Ma1, Yuan Chen2, Qinghua Zhang3, He Tian4, Jianming Wang5, Sanyun Liu6, Baoliang Wang7, Qian Wang8. 1. Department of Endocrinology, Jining No.1 People's Hospital, No. 6 Health Road, Rencheng District, Jining 272011, China. 2. Department of Endocrinology, Xinjiang Uiger Municipal People's Hospital, No. 91 Tianchi Road, Urumqi City, Xinjiang Uygur Autonomous Region, China. 3. Department of Endocrinology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, China. 4. Pharmacy Department, Zoucheng People's Hospital, Jining, Shandong 272000, China. 5. Internal Medicine Department, Traditional Chinese Medicine Hospital of Jining, Jining, Shandong 272000, China. 6. Cardiovascular Department, Traditional Chinese Medicine Hospital of Jining, Jining, Shandong 272000, China. 7. Pharmacy Department, Traditional Chinese Medicine Hospital of Sishui County, Jining, Shandong 272000, China. 8. Department of Spinal Surgery, Jining No.1 People's Hospital, No. 6 Health Road, Rencheng District, Jining 272011, China. Electronic address: monkey2335@sina.com.
Abstract
BACKGROUND: Interleukins (ILs), a multifunctional cytokine, play a fundamental role in inflammatory diseases, as well as in the development of osteoporosis. However, there are no data about the role of IL-16 polymorphism in development of osteoporosis. PATIENTS AND METHODS: In this study, we investigated the association between the IL-16 rs11556218 T/G and rs4072122 C/T polymorphisms respectively, and the risk of osteoporosis among 230 patients with osteoporosis and 230 healthy controls. Serum IL-16 level and its correlation with the IL-16 rs11556218 T/G genotypes were analyzed. RESULTS: Significant differences of genotype distribution were observed between osteoporosis cases and controls at the IL-16 rs11556218 T/G genotypes. Compared with the IL-16 rs11556218 T/G homozygote TT, the heterozygous TG genotype was associated with significantly increased risk for osteoporosis (OR=2.29, 95% CI=(1.15-3.82), p=0.026); the GG genotype was associated with increased risk for osteoporosis (OR=1.84, 95% CI=1.48-3.97, p=0.015). TG and GG combined variants that were associated with increased risk for osteoporosis compared with the TT genotype (OR=1.92, 95% CI=1.43-4.86, p=0.023). Moreover, in patients with osteoporosis, there was a correlation between the serum IL-16 and rs11556218 T/G genotype. However, the genotype and allele frequencies of IL-16 rs4072122 C/T polymorphisms in osteoporosis patients were not significantly different from controls. CONCLUSION: IL-16 rs11556218 T/G genotype was associated with increased risk for development of osteoporosis in Chinese postmenopausal women.
BACKGROUND: Interleukins (ILs), a multifunctional cytokine, play a fundamental role in inflammatory diseases, as well as in the development of osteoporosis. However, there are no data about the role of IL-16 polymorphism in development of osteoporosis. PATIENTS AND METHODS: In this study, we investigated the association between the IL-16rs11556218 T/G and rs4072122 C/T polymorphisms respectively, and the risk of osteoporosis among 230 patients with osteoporosis and 230 healthy controls. Serum IL-16 level and its correlation with the IL-16rs11556218 T/G genotypes were analyzed. RESULTS: Significant differences of genotype distribution were observed between osteoporosis cases and controls at the IL-16rs11556218 T/G genotypes. Compared with the IL-16rs11556218 T/G homozygote TT, the heterozygous TG genotype was associated with significantly increased risk for osteoporosis (OR=2.29, 95% CI=(1.15-3.82), p=0.026); the GG genotype was associated with increased risk for osteoporosis (OR=1.84, 95% CI=1.48-3.97, p=0.015). TG and GG combined variants that were associated with increased risk for osteoporosis compared with the TT genotype (OR=1.92, 95% CI=1.43-4.86, p=0.023). Moreover, in patients with osteoporosis, there was a correlation between the serum IL-16 and rs11556218 T/G genotype. However, the genotype and allele frequencies of IL-16rs4072122 C/T polymorphisms in osteoporosispatients were not significantly different from controls. CONCLUSION:IL-16rs11556218 T/G genotype was associated with increased risk for development of osteoporosis in Chinese postmenopausal women.