Cristina Pires Camargo1, Felipe Alexandre Fernandes2, Michel Hyo Mi Lee2, Luiza Campos Moreira Silva2, Julio Morais Besteiro3, Rolf Gemperli4. 1. Fellow PhD degree, Postgraduate Program in Surgical Clinics, Plastic Surgery Division, Faculty of Medicine, Universidade de São Paulo (FMUSP), Brazil. Scientific and intellectual content of the study, interpretation of data, critical revision. 2. Graduate student, School of Medicine, USP, Sao Paulo-SP, Brazil. Surgical procedures. 3. PhD, Department of Plastic Surgery, FMUSP, Sao Paulo-SP, Brazil. Interpretation of data, critical revision. 4. Full Professor and Head, Plastic Surgery Division, Department of Surgery, FMUSP, Sao Paulo-SP, Brazil. Scientific and intellectual content of the study, interpretation of data, critical revision.
Abstract
PURPOSE: : To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: : 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: : This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: : Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
PURPOSE: : To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: : 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: : This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: : Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
Authors: Cristina Pires Camargo; Renan Dias Frassei; Daniel Imbassahy de Sá Bittencourt Camara E Silva; Robert Zawadzki Pfann; Luiza de Campos Moreira da Silva; Julio Morais-Besteiro; Rolf Gemperli Journal: Acta Cir Bras Date: 2019-02-28 Impact factor: 1.388
Authors: C P Camargo; R Z Pfann; M S Kubrusly; M F R Silva; E T Guimarães; M S Leite; P H N Saldiva; R Gemperli Journal: Aesthetic Plast Surg Date: 2020-03-19 Impact factor: 2.708