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Literature DB >> 2798120

Polymers of random short oligonucleotides detect polymorphic loci in the human genome.

Abstract

Polymers of random 14 mer oligonucleotides are shown to detect discrete loci in the human genome. Eighteen different synthetic tandem repeats of random 14 base-pair units (STRs) have been generated and all of them turn out to detect polymorphic loci on southern blots of human DNA samples, presumably corresponding to a variable number of tandem repeats (VNTR). This finding suggests that minisatellites are a major component of the human genome and are strongly associated with the generation of genetic variability. In addition, it should open new strategies to make new polymorphic probes available.

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Year: 1989 PMID： 2798120 PMCID： PMC334871 DOI： 10.1093/nar/17.19.7623

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

27 in total

10. Inheritance in turnip of variable-number tandem-repeat genetic markers revealed with synthetic repetitive DNA probes.

Authors: S H Rogstad
Journal: Theor Appl Genet Date: 1994-12 Impact factor: 5.699

Polymers of random short oligonucleotides detect polymorphic loci in the human genome.

1. Cloning a selected fragment from a human DNA 'fingerprint': isolation of an extremely polymorphic minisatellite.

Review 2. Hybridization of nucleic acids immobilized on solid supports.

3. Genomic sequencing.

4. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

5. A highly polymorphic locus in human DNA.

6. Ignorant DNA?

7. Birth of a unique enzyme from an alternative reading frame of the preexisted, internally repetitious coding sequence.

8. Cryptic simplicity in DNA is a major source of genetic variation.

9. Structure and evolution of the human involucrin gene.

10. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1. Finding new human minisatellite sequences in the vicinity of long CA-rich sequences.

2. Modulation of polymorphic loci detection with synthetic tandem repeat variants.

3. Predicting human minisatellite polymorphism.

4. A synthetic probe STR 14C19, detects a new polymorphic locus at 16pter (D16S282).

5. A synthetic probe, STR 14C13, detects a new polymorphic locus on chromosome arm 7q (D7S450).

6. A synthetic probe, STR 16C17, detects a new polymorphic locus at 17pter (D17S450).

7. A synthetic probe, STR 16C2, detects a new polymorphic locus at 5pter (D5S206).

8. A synthetic probe, STR 16C18, detects a new polymorphic locus at 12qter (D12S55).

9. Repetitive DNA of grapevine: classes present and sequences suitable for cultivar identification.

10. Inheritance in turnip of variable-number tandem-repeat genetic markers revealed with synthetic repetitive DNA probes.