| Literature DB >> 27979284 |
Riccardo Nescatelli1, Simone Carradori2, Federico Marini3, Vicky Caponigro3, Remo Bucci3, Celeste De Monte4, Adriano Mollica2, Luisa Mannina5, Mariangela Ceruso6, Claudiu T Supuran7, Daniela Secci4.
Abstract
A microwave-assisted extraction method was optimised for the recovery of bioactive compounds from Crocus sativus L. stigmas with the use of water/ethanol mixture. HPLC-DAD was employed to evaluate the extraction parameters, in particular, solvent type and volume, and the duration of the procedure. Microwave-assisted extraction enhanced the recovery of the active principles, limiting extraction time and solvent waste. Moreover, NIR experiments were performed in order to compare spectra in pseudo-absorbance of Saffron samples with different geographical origins through the application of the chemometric techniques. Moreover, the biological evaluation of crocin 1, safranal and its semisynthetic derivatives as selective inhibitors of five isoforms of human carbonic anhydrase was also explored.Entities:
Keywords: Crocus sativus L.; Geographical origin; HPLC-DAD; Microwave-assisted extraction; NIR spectroscopy; Principal component analysis; hCA inhibitors
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Year: 2016 PMID： 27979284 DOI： 10.1016/j.foodchem.2016.11.086
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514