Literature DB >> 27978982

Pharmacogenomics in the age of personalized medicine.

Leslie J Dickmann1, Joseph A Ware2.   

Abstract

The aim of personalized medicine is to offer the right treatment to the right person at the right dose, thus maximizing efficacy and minimizing toxicity for each individual patient. Pharmacogenomic approaches attempt to refine the aim of personalized medicine by utilizing an individual's germline and somatic DNA signatures to guide treatment. In this review, we highlight the current use of pharmacogenomic based biomarker information in drug labeling. We also present several case studies on the implementation of pharmacogenomic strategies in drug discovery and development. Lastly, we comment on current challenges to implementing pharmacogenomic based testing in the clinic.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27978982     DOI： 10.1016/j.ddtec.2016.11.003

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  10 in total

1.  Pharmacogenomics Education Improves Pharmacy Student Perceptions of Their Abilities and Roles in Its Use.

Authors:  Rebecca Marcinak; Meaghan Paris; Shannon R M Kinney
Journal:  Am J Pharm Educ       Date:  2018-11       Impact factor: 2.047

2.  Lorazepam Challenge for Individuals at Varying Genetic Risk for Alzheimer Disease.

Authors:  Cynthia M Stonnington; Brian Harel; Dona E C Locke; Joseph G Hentz; Nan Zhang; Paul Maruff; Richard J Caselli
Journal:  Alzheimer Dis Assoc Disord       Date:  2017 Oct-Dec       Impact factor: 2.703

3.  Intensive care medicine in 2050: precision medicine.

Authors:  Hector R Wong
Journal:  Intensive Care Med       Date:  2017-02-24       Impact factor: 17.440

Review 4.  Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens.

Authors:  Prabodhika Mallikaratchy
Journal:  Molecules       Date:  2017-01-30       Impact factor: 4.411

5.  Genetic analysis of pharmacogenomic VIP variants in the Wa population from Yunnan Province of China.

Authors:  Dandan Li; Linna Peng; Shishi Xing; Chunjuan He; Tianbo Jin
Journal:  BMC Genom Data       Date:  2021-11-19

6.  Personalized Nursing Care in Precision-Medicine Era.

Authors:  Luís Carlos Lopes-Júnior
Journal:  SAGE Open Nurs       Date:  2021-12-09

Review 7.  Theranostic Interpolation of Genomic Instability in Breast Cancer.

Authors:  Rabia Rasool; Inam Ullah; Bismillah Mubeen; Sultan Alshehri; Syed Sarim Imam; Mohammed M Ghoneim; Sami I Alzarea; Fahad A Al-Abbasi; Bibi Nazia Murtaza; Imran Kazmi; Muhammad Shahid Nadeem
Journal:  Int J Mol Sci       Date:  2022-02-07       Impact factor: 5.923

Review 8.  Ethnic Diversity and Warfarin Pharmacogenomics.

Authors:  Innocent G Asiimwe; Munir Pirmohamed
Journal:  Front Pharmacol       Date:  2022-04-04       Impact factor: 5.988

9.  Assessment of the Implementation of Pharmacogenomic Testing in a Pediatric Tertiary Care Setting.

Authors:  Iris Cohn; Roozbeh Manshaei; Eriskay Liston; John B A Okello; Reem Khan; Meredith R Curtis; Abby J Krupski; Rebekah K Jobling; Kelsey Kalbfleisch; Tara A Paton; Miriam S Reuter; Robin Z Hayeems; Ruud H J Verstegen; Aaron Goldman; Raymond H Kim; Shinya Ito
Journal:  JAMA Netw Open       Date:  2021-05-03

Review 10.  Precision health: A nursing perspective.

Authors:  Mei R Fu; Emma Kurnat-Thoma; Angela Starkweather; Wendy A Henderson; Ann K Cashion; Janet K Williams; Maria C Katapodi; Karin Reuter-Rice; Kathleen T Hickey; Veronica Barcelona de Mendoza; Kathleen Calzone; Yvette P Conley; Cindy M Anderson; Debra E Lyon; Michael T Weaver; Pamela K Shiao; Rose E Constantino; Shu-Fen Wung; Marilyn J Hammer; Joachim G Voss; Bernice Coleman
Journal:  Int J Nurs Sci       Date:  2019-12-24
  10 in total

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