Literature DB >> 27977481

Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?

J Mario Wolosin1, Robert Ritch2, Audrey M Bernstein1,3.   

Abstract

In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from exfoliation syndrome glaucoma patients at the time of surgery and discuss the potential implications of these findings for understanding the cellular sources of the disease.

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Year:  2018        PMID： 27977481      PMCID： PMC5468508          DOI： 10.1097/IJG.0000000000000606

Source DB:  PubMed          Journal:  J Glaucoma        ISSN： 1057-0829            Impact factor:   2.503


  30 in total

1.  Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome.

Authors:  Matthias Zenkel; Anita Krysta; Francesca Pasutto; Anselm Juenemann; Friedrich E Kruse; Ursula Schlötzer-Schrehardt
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-10-31       Impact factor: 4.799

2.  Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells.

Authors:  Jin-Gu Lee; Shokichi Takahama; Guofeng Zhang; Stanislav I Tomarev; Yihong Ye
Journal:  Nat Cell Biol       Date:  2016-06-13       Impact factor: 28.824

3.  Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma.

Authors:  Matthias Zenkel; Piotr Lewczuk; Anselm Jünemann; Friedrich E Kruse; Gottfried O H Naumann; Ursula Schlötzer-Schrehardt
Journal:  Am J Pathol       Date:  2010-04-15       Impact factor: 4.307

Review 4.  Prospects for gene-environment interactions in exfoliation syndrome.

Authors:  Louis R Pasquale; Jae H Kang; Janey L Wiggs
Journal:  J Glaucoma       Date:  2014 Oct-Nov       Impact factor: 2.503

Review 5.  Expression and regulation of LOXL1 and elastin-related genes in eyes with exfoliation syndrome.

Authors:  Matthias Zenkel; Ursula Schlötzer-Schrehardt
Journal:  J Glaucoma       Date:  2014 Oct-Nov       Impact factor: 2.503

6.  A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Authors:  Tin Aung; Mineo Ozaki; Takanori Mizoguchi; R Rand Allingham; Zheng Li; Aravind Haripriya; Satoko Nakano; Steffen Uebe; Jeffrey M Harder; Anita S Y Chan; Mei Chin Lee; Kathryn P Burdon; Yury S Astakhov; Khaled K Abu-Amero; Juan C Zenteno; Yildirim Nilgün; Tomasz Zarnowski; Mohammad Pakravan; Leen Abu Safieh; Liyun Jia; Ya Xing Wang; Susan Williams; Daniela Paoli; Patricio G Schlottmann; Lulin Huang; Kar Seng Sim; Jia Nee Foo; Masakazu Nakano; Yoko Ikeda; Rajesh S Kumar; Morio Ueno; Shin-ichi Manabe; Ken Hayashi; Shigeyasu Kazama; Ryuichi Ideta; Yosai Mori; Kazunori Miyata; Kazuhisa Sugiyama; Tomomi Higashide; Etsuo Chihara; Kenji Inoue; Satoshi Ishiko; Akitoshi Yoshida; Masahide Yanagi; Yoshiaki Kiuchi; Makoto Aihara; Tsutomu Ohashi; Toshiya Sakurai; Takako Sugimoto; Hideki Chuman; Fumihiko Matsuda; Kenji Yamashiro; Norimoto Gotoh; Masahiro Miyake; Sergei Y Astakhov; Essam A Osman; Saleh A Al-Obeidan; Ohoud Owaidhah; Leyla Al-Jasim; Sami Al Shahwan; Rhys A Fogarty; Paul Leo; Yaz Yetkin; Çilingir Oğuz; Mozhgan Rezaei Kanavi; Afsaneh Nederi Beni; Shahin Yazdani; Evgeny L Akopov; Kai-Yee Toh; Gareth R Howell; Andrew C Orr; Yufen Goh; Wee Yang Meah; Su Qin Peh; Ewa Kosior-Jarecka; Urszula Lukasik; Mandy Krumbiegel; Eranga N Vithana; Tien Yin Wong; Yutao Liu; Allison E Ashley Koch; Pratap Challa; Robyn M Rautenbach; David A Mackey; Alex W Hewitt; Paul Mitchell; Jie Jin Wang; Ari Ziskind; Trevor Carmichael; Rangappa Ramakrishnan; Kalpana Narendran; Rangaraj Venkatesh; Saravanan Vijayan; Peiquan Zhao; Xueyi Chen; Dalia Guadarrama-Vallejo; Ching Yu Cheng; Shamira A Perera; Rahat Husain; Su-Ling Ho; Ulrich-Christoph Welge-Luessen; Christian Mardin; Ursula Schloetzer-Schrehardt; Axel M Hillmer; Stefan Herms; Susanne Moebus; Markus M Nöthen; Nicole Weisschuh; Rohit Shetty; Arkasubhra Ghosh; Yik Ying Teo; Matthew A Brown; Ignacio Lischinsky; Jonathan G Crowston; Michael Coote; Bowen Zhao; Jinghong Sang; Nihong Zhang; Qisheng You; Vera Vysochinskaya; Panayiota Founti; Anthoula Chatzikyriakidou; Alexandros Lambropoulos; Eleftherios Anastasopoulos; Anne L Coleman; M Roy Wilson; Douglas J Rhee; Jae Hee Kang; Inna May-Bolchakova; Steffen Heegaard; Kazuhiko Mori; Wallace L M Alward; Jost B Jonas; Liang Xu; Jeffrey M Liebmann; Balram Chowbay; Elke Schaeffeler; Matthias Schwab; Fabian Lerner; Ningli Wang; Zhenglin Yang; Paolo Frezzotti; Shigeru Kinoshita; John H Fingert; Masaru Inatani; Kei Tashiro; André Reis; Deepak P Edward; Louis R Pasquale; Toshiaki Kubota; Janey L Wiggs; Francesca Pasutto; Fotis Topouzis; Michael Dubina; Jamie E Craig; Nagahisa Yoshimura; Periasamy Sundaresan; Simon W M John; Robert Ritch; Michael A Hauser; Chiea-Chuen Khor
Journal:  Nat Genet       Date:  2015-02-23       Impact factor: 38.330

7.  Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography.

Authors:  Sasan Moghimi; Mehdi Mazloumi; MohammadKarim Johari; Parisa Abdi; Ghasem Fakhraie; Massood Mohammadi; Reza Zarei; Yadollah Eslami; Masoud A Fard; Shan C Lin
Journal:  Invest Ophthalmol Vis Sci       Date:  2016-03       Impact factor: 4.799

Review 8.  Systemic Associations of Exfoliation Syndrome.

Authors:  Robert Ritch
Journal:  Asia Pac J Ophthalmol (Phila)       Date:  2016 Jan-Feb

9.  MALDI MS imaging analysis of apolipoprotein E and lysyl oxidase-like 1 in human lens capsules affected by pseudoexfoliation syndrome.

Authors:  Maurizio Ronci; Shiwani Sharma; Sarah Martin; Jamie E Craig; Nicolas H Voelcker
Journal:  J Proteomics       Date:  2013-02-11       Impact factor: 4.044

10.  Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo.

Authors:  Maretoshi Hirai; Tetsuya Ohbayashi; Masahito Horiguchi; Katsuya Okawa; Akari Hagiwara; Kenneth R Chien; Toru Kita; Tomoyuki Nakamura
Journal:  J Cell Biol       Date:  2007-03-19       Impact factor: 10.539
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  4 in total

Review 1.  Alternate Causes for Pathogenesis of Exfoliation Glaucoma, a Multifactorial Elastotic Disorder: A Literature Review.

Authors:  Munmun Chakraborty; Aparna Rao
Journal:  Curr Issues Mol Biol       Date:  2022-03-01       Impact factor: 2.976

Review 2.  Exfoliation Syndrome: A Disease of Autophagy and LOXL1 Proteopathy.

Authors:  Audrey M Bernstein; Robert Ritch; Jose M Wolosin
Journal:  J Glaucoma       Date:  2018-07       Impact factor: 2.503

3.  Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis.

Authors:  Diego Sbardella; Grazia Raffaella Tundo; Massimo Coletta; Gianluca Manni; Francesco Oddone
Journal:  Int J Mol Sci       Date:  2021-05-31       Impact factor: 5.923

4.  Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway.

Authors:  Hong-Yan Du; Rong Wang; Jian-Liang Li; Huang Luo; Xiao-Yan Xie; Ran Yan; Yue-Ling Jian; Jin-Ying Cai
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269
  4 in total

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