| Literature DB >> 27977195 |
Federica Buonerba1, Susan Lepri1, Laura Goracci1, Bryan D Schindler2, Susan M Seo2, Glenn W Kaatz2,3, Gabriele Cruciani1.
Abstract
The NorA efflux pump is a potential drug target for reversal of resistance to selected antibacterial agents, and recently we described indole-based inhibitor candidates. Herein we report a second class of inhibitors derived from them but with significant differences in shape and size. In particular, compounds 13 and 14 are very potent inhibitors in that they demonstrated the lowest IC50 values (2 μM) ever observed among all indole-based compounds we have evaluated.Entities:
Mesh：
Substances：
Year: 2016 PMID： 27977195 DOI： 10.1021/acs.jmedchem.6b01281
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446