Literature DB >> 27977007

The value of genetic testing: beyond clinical utility.

Barbara Lerner1, Nell Marshall2, Sabine Oishi2, Andrew Lanto2, Martin Lee2, Alison B Hamilton2,3, Elizabeth M Yano2,4, Maren T Scheuner2,5.   

Abstract

OBJECTIVE: To assess the value of genetic testing from the perspective of the Department of Veterans Affairs (VA) clinical leadership.
METHODS: We administered an Internet-based survey to VA clinical leaders nationwide. Respondents rated the value (on a 5-point scale) of each of six possible reasons for genetic testing. Bivariate and linear regressions identified associations between value ratings and environmental, organizational, provider, patient, and encounter characteristics.
RESULTS: Respondents (n = 353; 63% response rate) represented 92% of VA medical centers. Tests that inform clinical management had the highest value rating (58.6%), followed by tests that inform disease prevention (56.4%), reproductive options (50.1%), life planning (43.9%), and a suspected (39.9%) or established (32.3%) diagnosis. Factors positively associated with high value included a culture that fosters adoption of genomics, specialist versus primary care provider, genetic tests available on laboratory menus, availability of genetic testing guidelines, clinicians knowing when to request genetics referrals, and availability of genetics professionals.
CONCLUSION: Our results demonstrate the varied value of genetic testing from the perspective of clinical leadership within a health-care system. Engaging organizational leadership in understanding the various reasons for genetic testing and its value beyond clinical utility may increase adoption of genetic tests to support patient-centered care.Genet Med advance online publication 15 December 2016.

Entities:  

Mesh:

Year:  2016        PMID: 27977007     DOI: 10.1038/gim.2016.186

Source DB:  PubMed          Journal:  Genet Med        ISSN: 1098-3600            Impact factor:   8.822


  28 in total

Review 1.  From understanding health care provider behavior to improving health care: the QUERI framework for quality improvement. Quality Enhancement Research Initiative.

Authors:  L V Rubenstein; B S Mittman; E M Yano; C D Mulrow
Journal:  Med Care       Date:  2000-06       Impact factor: 2.983

2.  How can we assess the value of complex medical innovations in practice?

Authors:  Payam Abrishami; Albert Boer; Klasien Horstman
Journal:  Expert Rev Pharmacoecon Outcomes Res       Date:  2015-06       Impact factor: 2.217

3.  Debating the clinical utility of direct-to-consumer genetic testing for addiction susceptibility.

Authors:  Pascal Borry; Lidewij Henneman
Journal:  Addiction       Date:  2012-12       Impact factor: 6.526

4.  What's in a setting?: Influence of organizational culture on provider adherence to clinical guidelines for treating tobacco use.

Authors:  Dorothy Y Hung; Robynn Leidig; Donna R Shelley
Journal:  Health Care Manage Rev       Date:  2014 Apr-Jun

5.  Association between information provision and decisional conflict in cancer patients.

Authors:  J A Sim; J S Shin; S M Park; Y J Chang; A Shin; D Y Noh; W Han; H K Yang; H J Lee; Y W Kim; Y T Kim; S Y Jeong; J H Yoon; Y J Kim; D S Heo; T Y Kim; D Y Oh; H G Wu; H J Kim; E K Chie; K W Kang; Y H Yun
Journal:  Ann Oncol       Date:  2015-06-26       Impact factor: 32.976

6.  Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients.

Authors:  Natalie Ngoi; Soo-Chin Lee; Mikael Hartman; Lay-Wai Khin; Andrea Wong
Journal:  Breast       Date:  2012-05-04       Impact factor: 4.380

7.  Attitudes and knowledge of medical practitioners to hereditary cancer clinics and cancer genetic testing.

Authors:  Ian Teng; Allan Spigelman
Journal:  Fam Cancer       Date:  2014-06       Impact factor: 2.375

8.  Outcomes of interest in evidence-based evaluations of genetic tests.

Authors:  Jeffrey R Botkin; Steven M Teutsch; Celia I Kaye; Maxine Hayes; James E Haddow; Linda A Bradley; Kathleen Szegda; W David Dotson
Journal:  Genet Med       Date:  2010-04       Impact factor: 8.822

9.  Clinical utility of genetic and genomic services: a position statement of the American College of Medical Genetics and Genomics.

Authors: 
Journal:  Genet Med       Date:  2015-03-12       Impact factor: 8.822

10.  Factors influencing organizational adoption and implementation of clinical genetic services.

Authors:  Alison B Hamilton; Sabine Oishi; Elizabeth M Yano; Cynthia E Gammage; Nell J Marshall; Maren T Scheuner
Journal:  Genet Med       Date:  2013-08-15       Impact factor: 8.822

View more
  7 in total

1.  High Rates of Genetic Diagnosis in Psychiatric Patients with and without Neurodevelopmental Disorders: Toward Improved Genetic Diagnosis in Psychiatric Populations.

Authors:  Joyce So; Venuja Sriretnakumar; Jessica Suddaby; Brianna Barsanti-Innes; Hanna Faghfoury; Timothy Gofine
Journal:  Can J Psychiatry       Date:  2020-06-04       Impact factor: 4.356

2.  A Modern Approach to Dyslipidemia.

Authors:  Amanda J Berberich; Robert A Hegele
Journal:  Endocr Rev       Date:  2022-07-13       Impact factor: 25.261

3.  Pulmonary arterial hypertension: Specialists' knowledge, practices, and attitudes of genetic counseling and genetic testing in the USA.

Authors:  Joseph E Jacher; Lisa J Martin; Wendy K Chung; James E Loyd; William C Nichols
Journal:  Pulm Circ       Date:  2017-03-27       Impact factor: 3.017

4.  Physician Experience with Direct-To-Consumer Genetic Testing in Kaiser Permanente.

Authors:  M Cabell Jonas; Pim Suwannarat; Andrea Burnett-Hartman; Nikki Carroll; Michelle Turner; Kristen Janes; Christine Truong; Erica Blum-Barnett; Nazneen Aziz; Elizabeth A McGlynn
Journal:  J Pers Med       Date:  2019-11-01

5.  Primary Care Physician Experiences with Integrated Population-Scale Genetic Testing: A Mixed-Methods Assessment.

Authors:  Amy A Lemke; Laura M Amendola; Kristine Kuchta; Henry M Dunnenberger; Jennifer Thompson; Christian Johnson; Nadim Ilbawi; Lauren Oshman; Peter J Hulick
Journal:  J Pers Med       Date:  2020-10-13

6.  Preanalytical DNA assessment for downstream applications: How to optimize the management of human biospecimens to support molecular diagnosis-An experimental study.

Authors:  Marina Mordenti; Valentina Capicchioni; Serena Corsini; Manuela Locatelli; Elisabetta Abelli; Federico Banchelli; Manila Boarini; Luca Sangiorgi
Journal:  J Clin Lab Anal       Date:  2022-06-06       Impact factor: 3.124

7.  Clinical application of fetal genome-wide sequencing during pregnancy: position statement of the Canadian College of Medical Geneticists.

Authors:  Kym Boycott; Christine M Armour; Joanna Lazier; Taila Hartley; Jo-Ann Brock; Oana Caluseriu; David Chitayat; Anne-Marie Laberge; Sylvie Langlois; Julie Lauzon; Tanya N Nelson; Jillian Parboosingh; Dimitri J Stavropoulos
Journal:  J Med Genet       Date:  2021-09-20       Impact factor: 5.941

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.