Literature DB >> 27976863

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

Atsushi Yagishita1, Tasuku Ueno2, Hiroyasu Esumi3, Hideyuki Saya1, Kazuhiro Kaneko, Katsuya Tsuchihara, Yasuteru Urano2.   

Abstract

Aldehyde dehydrogenase (ALDH) is overexpressed in some subpopulations of stem cells and cancer cells. We have designed and synthesized the first selective fluorescent probe for class 3 ALDH (ALDH3A1). This probe enabled the visualization of ALDH3A1-positive cells by fluorescence microscopy as well as flow-cytometric isolation of ALDH3A1-positive viable cells from a human Caucasian esophageal squamous cell line (OE21) that heterogeneously expresses ALDH3A1.

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Year:  2016        PMID： 27976863     DOI： 10.1021/acs.bioconjchem.6b00618

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  4 in total

Review 1.  Advances in Activity-Based Sensing Probes for Isoform-Selective Imaging of Enzymatic Activity.

Authors:  Sarah H Gardner; Christopher J Reinhardt; Jefferson Chan
Journal:  Angew Chem Int Ed Engl       Date:  2020-09-11       Impact factor: 15.336

Review 2.  Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives.

Authors:  Qiang Jin; JingJing Wu; Yue Wu; Hongxin Li; Moshe Finel; Dandan Wang; Guangbo Ge
Journal:  Acta Pharm Sin B       Date:  2022-01-21       Impact factor: 14.903

3.  Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1.

Authors:  Chelsea Anorma; Jamila Hedhli; Thomas E Bearrood; Nicholas W Pino; Sarah H Gardner; Hiroshi Inaba; Pamela Zhang; Yanfen Li; Daven Feng; Sara E Dibrell; Kristopher A Kilian; Lawrence W Dobrucki; Timothy M Fan; Jefferson Chan
Journal:  ACS Cent Sci       Date:  2018-07-25       Impact factor: 14.553

4.  Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells.

Authors:  Sebastiaan T A Koenders; Lukas S Wijaya; Martje N Erkelens; Alexander T Bakker; Vera E van der Noord; Eva J van Rooden; Lindsey Burggraaff; Pasquale C Putter; Else Botter; Kim Wals; Hans van den Elst; Hans den Dulk; Bogdan I Florea; Bob van de Water; Gerard J P van Westen; Reina E Mebius; Herman S Overkleeft; Sylvia E Le Dévédec; Mario van der Stelt
Journal:  ACS Cent Sci       Date:  2019-12-12       Impact factor: 14.553
  4 in total

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