Literature DB >> 27974342

Use of thromboelastography in the management of liver cirrhosis and accelerated intravascular coagulation and fibrinolysis (AICF).

Thomas Joseph Peterson1, Allison Margaret Brown Webb2, Benjamin Samuel Vipler3.   

Abstract

In the presented case, the authors describe an obese middle-aged man that presented to the emergency department for persistent oedema, scleral icterus and fatigue. He was admitted to the hospital and diagnosed with liver cirrhosis via transjugular liver biopsy. He continued to bleed from the biopsy site for 5 days from accelerated intravascular coagulation and fibrinolysis (AICF) requiring multiple transfusions of packed red blood cells, fresh-frozen plasma and cryoprecipitate. The authors then used thromboelastography (TEG) to further characterise the patient's coagulopathy, which revealed platelet inhibition. The results of the TEG significantly changed future transfusion management. Finally, the authors conducted a literature review to summarise the current literature available for the use of TEG in the management of liver cirrhosis with AICF. 2016 BMJ Publishing Group Ltd.

Entities:  

Mesh:

Year:  2016        PMID: 27974342      PMCID: PMC5174901          DOI: 10.1136/bcr-2016-218294

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  12 in total

Review 1.  Transfusion guidelines: when to transfuse.

Authors:  Zbigniew M Szczepiorkowski; Nancy M Dunbar
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2013

2.  Infection and hemostasis in decompensated cirrhosis: a prospective study using thrombelastography.

Authors:  G V Papatheodoridis; D Patch; G J Webster; J Brooker; E Barnes; A K Burroughs
Journal:  Hepatology       Date:  1999-04       Impact factor: 17.425

Review 3.  The platelet P2 receptors as molecular targets for old and new antiplatelet drugs.

Authors:  Christian Gachet
Journal:  Pharmacol Ther       Date:  2005-06-13       Impact factor: 12.310

4.  Potential applications of thromboelastography in patients with acute and chronic liver disease.

Authors:  R Todd Stravitz
Journal:  Gastroenterol Hepatol (N Y)       Date:  2012-08

5.  Hypercoagulability in patients with primary biliary cirrhosis and primary sclerosing cholangitis evaluated by thrombelastography.

Authors:  Z Ben-Ari; M Panagou; D Patch; S Bates; E Osman; J Pasi; A Burroughs
Journal:  J Hepatol       Date:  1997-03       Impact factor: 25.083

6.  Competitions between fibrinogen with its degradation products for interactions with the platelet-fibrinogen receptor.

Authors:  L I Thorsen; F Brosstad; G Gogstad; K Sletten; N O Solum
Journal:  Thromb Res       Date:  1986-12-01       Impact factor: 3.944

7.  The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters.

Authors:  Armando Tripodi; Massimo Primignani; Veena Chantarangkul; Ylenia Viscardi; Alessandra Dell'Era; Federica M Fabris; Pier Mannuccio Mannucci
Journal:  Thromb Res       Date:  2009-01-09       Impact factor: 3.944

8.  Coagulopathy in liver disease: a balancing act.

Authors:  Jody L Kujovich
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2015

9.  Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study.

Authors:  Paolo Montalto; Jiannis Vlachogiannakos; Dominic J Cox; Sabrina Pastacaldi; David Patch; Andrew K Burroughs
Journal:  J Hepatol       Date:  2002-10       Impact factor: 25.083

10.  Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial.

Authors:  Lesley De Pietri; Marcello Bianchini; Roberto Montalti; Nicola De Maria; Tommaso Di Maira; Bruno Begliomini; Giorgio Enrico Gerunda; Fabrizio di Benedetto; Guadalupe Garcia-Tsao; Erica Villa
Journal:  Hepatology       Date:  2015-12-09       Impact factor: 17.425

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  2 in total

1.  Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference.

Authors:  N M Intagliata; C K Argo; J G Stine; T Lisman; S H Caldwell; F Violi
Journal:  Thromb Haemost       Date:  2018-07-30       Impact factor: 5.249

2.  ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs.

Authors:  Cynthia R L Webster; Sharon A Center; John M Cullen; Dominique G Penninck; Keith P Richter; David C Twedt; Penny J Watson
Journal:  J Vet Intern Med       Date:  2019-03-07       Impact factor: 3.333

  2 in total

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