Victor Germain1, Tienhan Sandrine Dabakuyo-Yonli2, Sophie Marilier1, Alain Putot1, Leila Bengrine-Lefevre3, Patrick Arveux2, Patrick Manckoundia4, Valérie Quipourt1. 1. Department of Geriatrics and Internal Medicine, Hospital of Champmaillot, University Hospital, Dijon, France; Geriatric Oncology Coordination Unit in Burgundy, University Hospital, Dijon, France. 2. Côte d'Or Breast and Gynaecological Cancer Registry, Centre George François Leclerc, 1 rue du Professeur Marion, BP 77980, Dijon Cedex, France; National Clinical Research Platform for Quality of Life in Oncology, France. 3. Medical Oncology Department, Centre George François Leclerc, 1 rue du Professeur Marion, BP 77980, Dijon Cedex, France. 4. Department of Geriatric Rehabilitation, Hospital of Champmaillot, University Hospital, Dijon F-21079, France; UMR Inserm/U1093 Cognition, Action, Sensorimotor Plasticity, University of Burgundy, Dijon, France. Electronic address: patrick.manckoundia@chu-dijon.fr.
Abstract
OBJECTIVE: To evaluate the perceived burden and the quality of life (QoL) at 3 and 6months of the primary caregiver (PC) of patients aged 70 and over suffering from cancer and the predictors of QoL in this population. METHODS: In this prospective observational study, 98 patients aged 70 and older with cancer and 96 PCs were included between 01/06/2014 and 18/03/2015. The Medical Outcomes Study 12-item Short Form Health Survey (SF-12) was used to assess the QoL of PCs and the Zarit Burden Interview (ZBI) was used to measure the perceived burden at 3 and 6months. The major determinants of QoL were identified using mixed linear models for the dimensions of the SF-12 that showed an average difference of at least 5 points between baseline and follow-up at 6months. RESULTS: The QoL scores of PCs showed a decrease in the dimensions "role emotional" and "bodily pain" over 6months. In multivariate analysis, the main determinants of QoL for "role emotional" were the PC's age (p=0.005), a low perceived burden (p<0.0001) and a functionally independent patient (p=0.01), and for "bodily pain" was a low perceived burden (p<0.0001) and the non-use of hormone therapy during the treatment (p<0.0001). CONCLUSION: The main determinants of the QoL of PCs concerned factors inherent to the PC (age and perceived burden) and patient (functional independence).
OBJECTIVE: To evaluate the perceived burden and the quality of life (QoL) at 3 and 6months of the primary caregiver (PC) of patients aged 70 and over suffering from cancer and the predictors of QoL in this population. METHODS: In this prospective observational study, 98 patients aged 70 and older with cancer and 96 PCs were included between 01/06/2014 and 18/03/2015. The Medical Outcomes Study 12-item Short Form Health Survey (SF-12) was used to assess the QoL of PCs and the Zarit Burden Interview (ZBI) was used to measure the perceived burden at 3 and 6months. The major determinants of QoL were identified using mixed linear models for the dimensions of the SF-12 that showed an average difference of at least 5 points between baseline and follow-up at 6months. RESULTS: The QoL scores of PCs showed a decrease in the dimensions "role emotional" and "bodily pain" over 6months. In multivariate analysis, the main determinants of QoL for "role emotional" were the PC's age (p=0.005), a low perceived burden (p<0.0001) and a functionally independent patient (p=0.01), and for "bodily pain" was a low perceived burden (p<0.0001) and the non-use of hormone therapy during the treatment (p<0.0001). CONCLUSION: The main determinants of the QoL of PCs concerned factors inherent to the PC (age and perceived burden) and patient (functional independence).
Authors: Lee A Kehoe; Huiwen Xu; Paul Duberstein; Kah Poh Loh; Eva Culakova; Beverly Canin; Arti Hurria; William Dale; Megan Wells; Nikesha Gilmore; Amber S Kleckner; Jennifer Lund; Charles Kamen; Marie Flannery; Mike Hoerger; Judith O Hopkins; Jane Jijun Liu; Jodi Geer; Ron Epstein; Supriya G Mohile Journal: J Am Geriatr Soc Date: 2019-03-29 Impact factor: 5.562
Authors: Supriya G Mohile; William Dale; Mark R Somerfield; Mara A Schonberg; Cynthia M Boyd; Peggy S Burhenn; Beverly Canin; Harvey Jay Cohen; Holly M Holmes; Judith O Hopkins; Michelle C Janelsins; Alok A Khorana; Heidi D Klepin; Stuart M Lichtman; Karen M Mustian; William P Tew; Arti Hurria Journal: J Clin Oncol Date: 2018-05-21 Impact factor: 44.544
Authors: Yingzi Zhang; Supriya Mohile; Eva Culakova; Sally Norton; Kah Poh Loh; Sindhuja Kadambi; Lee Kehoe; Valerie Aarne Grossman; Victor G Vogel; Brian L Burnette; Thomas P Bradley; Marie Flannery Journal: Psychooncology Date: 2022-02-20 Impact factor: 3.955