Myung Hoon Hahn1, Ye-Yeon Won2. 1. Department of Orthopaedics, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Cheonan, Korea. 2. Department of Orthopaedics, Ajou University School of Medicine, Suwon, Korea.
Abstract
BACKGROUND: Recently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture. METHODS: This study was conducted with 178 female osteoporotic hip fracture patients. Total hip BMD was measured using dual energy X-ray absorptiometry. Cross-sectional area (CSA), cross-sectional muscle area (CSmA), muscle attenuation coefficient (MAC), and intramuscular adipose tissue (IMAT) of gluteus maximus, hip abductors, quadriceps and hamstring muscle were measured with computed tomography. Normalized IMAT (nIMAT) was calculated by dividing the fat area in the muscle into the size of each muscle. The correlation between each measurement is examined then the differences between the intertrochanteric fracture group and the femoral neck fracture group were analyzed. RESULTS: CSmA and MAC of quadriceps were the largest and nIMAT was the lowest. CSA and CSmA of the four muscles showed a statistically significant positive correlation with weight, height, body mass index (BMI), and BMD. MAC of 2 gluteal muscles was positively correlated with weight, BMI and BMD. nIMAT of all four muscles was positively correlation with weight and BMI but nIMAT of 2 mid-thigh muscles was positively correlation with BMD. CONCLUSIONS: Muscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. BMD was positively correlation with CSA and CSmA of all thigh muscles, and MAC of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.
BACKGROUND: Recently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture. METHODS: This study was conducted with 178 female osteoporotic hip fracturepatients. Total hip BMD was measured using dual energy X-ray absorptiometry. Cross-sectional area (CSA), cross-sectional muscle area (CSmA), muscle attenuation coefficient (MAC), and intramuscular adipose tissue (IMAT) of gluteus maximus, hip abductors, quadriceps and hamstring muscle were measured with computed tomography. Normalized IMAT (nIMAT) was calculated by dividing the fat area in the muscle into the size of each muscle. The correlation between each measurement is examined then the differences between the intertrochanteric fracture group and the femoral neck fracture group were analyzed. RESULTS: CSmA and MAC of quadriceps were the largest and nIMAT was the lowest. CSA and CSmA of the four muscles showed a statistically significant positive correlation with weight, height, body mass index (BMI), and BMD. MAC of 2 gluteal muscles was positively correlated with weight, BMI and BMD. nIMAT of all four muscles was positively correlation with weight and BMI but nIMAT of 2 mid-thigh muscles was positively correlation with BMD. CONCLUSIONS: Muscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. BMD was positively correlation with CSA and CSmA of all thigh muscles, and MAC of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.
Entities:
Keywords:
Bone density; Fatty degeneration; Hip fractures; Muscle attenuation; Osteoporosis
Authors: B H Goodpaster; C L Carlson; M Visser; D E Kelley; A Scherzinger; T B Harris; E Stamm; A B Newman Journal: J Appl Physiol (1985) Date: 2001-06
Authors: Marjolein Visser; Stephen B Kritchevsky; Bret H Goodpaster; Anne B Newman; Michael Nevitt; Elizabeth Stamm; Tamara B Harris Journal: J Am Geriatr Soc Date: 2002-05 Impact factor: 5.562
Authors: Anne L Schafer; Eric Vittinghoff; Thomas F Lang; Deborah E Sellmeyer; Tamara B Harris; Alka M Kanaya; Elsa S Strotmeyer; Peggy M Cawthon; Steven R Cummings; Frances A Tylavsky; Ann L Scherzinger; Ann V Schwartz Journal: J Clin Endocrinol Metab Date: 2010-07-28 Impact factor: 5.958
Authors: Bret H Goodpaster; Seok Won Park; Tamara B Harris; Steven B Kritchevsky; Michael Nevitt; Ann V Schwartz; Eleanor M Simonsick; Frances A Tylavsky; Marjolein Visser; Anne B Newman Journal: J Gerontol A Biol Sci Med Sci Date: 2006-10 Impact factor: 6.053
Authors: Serghei Malkov; Peggy M Cawthon; Kathy Wilt Peters; Jane A Cauley; Rachel A Murphy; Marjolein Visser; Joseph P Wilson; Tamara Harris; Suzanne Satterfield; Steve Cummings; John A Shepherd Journal: J Bone Miner Res Date: 2015-05-21 Impact factor: 6.741
Authors: Katie G W Bouche; Olivier Vanovermeire; Veerle K Stevens; Pascal L Coorevits; Jacques J Caemaert; Dirk C Cambier; Koenraad Verstraete; Guy G Vanderstraeten; Lieven A Danneels Journal: BMC Musculoskelet Disord Date: 2011-03-31 Impact factor: 2.362
Authors: Mario Inacio; Alice S Ryan; Woei-Nan Bair; Michelle Prettyman; Brock A Beamer; Mark W Rogers Journal: BMC Geriatr Date: 2014-03-25 Impact factor: 3.921
Authors: Egon Burian; Jan Syväri; Michael Dieckmeyer; Christina Holzapfel; Theresa Drabsch; Nico Sollmann; Jan S Kirschke; Ernst J Rummeny; Claus Zimmer; Hans Hauner; Dimitrios C Karampinos; Thomas Baum; Daniela Junker Journal: Sci Rep Date: 2020-06-16 Impact factor: 4.379