M Earth Hasassri1, Eric R Jackson1, Husam Ghawi2, Eell Ryoo3, Chung-Il Wi4, Mark G Bartlett5, Gerald W Volcheck6, Christopher R Moir7, Euijung Ryu8, Young J Juhn9. 1. Mayo Medical School, Mayo Clinic, Rochester, Minn. 2. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn. 3. Department of Pediatrics, Gil Hospital, Gachon University School of Medicine, Inchon, South Korea. 4. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Pediatric Asthma Epidemiology Research Unit, Mayo Clinic, Rochester, Minn. 5. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minn. 6. Department of Pediatrics, Division of Allergic Diseases, Mayo Clinic, Rochester, Minn. 7. Department of Pediatric Surgery, Mayo Clinic, Rochester, Minn. 8. Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. 9. Department of Pediatric and Adolescent Medicine/Internal Medicine, Mayo Clinic, Rochester, Minn; Pediatric Asthma Epidemiology Research Unit, Mayo Clinic, Rochester, Minn. Electronic address: juhn.young@mayo.edu.
Abstract
OBJECTIVE: To assess whether asthma is associated with risk of appendicitis in children. METHODS: We used a population-based case-control study design using a comprehensive medical record review and predetermined criteria for appendicitis and asthma. All children (age younger than 18 years of age) who resided in Olmsted County, Minnesota, and developed appendicitis between 2006 and 2012 were matched to controls (1:1) with regard to birthday, gender, registration date, and index date. Asthma status was ascertained using predetermined criteria. Active (current) asthma was defined as the presence of asthma symptoms or asthma-related events (eg, medication use, clinic visits, emergency department, or hospitalization) within 1 year before the index date. Inactive asthma was defined as subjects without these events. A conditional logistic regression model was used. RESULTS: Among the 309 appendicitis cases identified, when stratified according to asthma status, active asthma was associated with significantly increased risk of appendicitis compared with inactive asthma (odds ratio [OR] = 2.48; 95% confidence interval [CI], 1.22-5.03) and to no asthma (OR = 1.88; 95% CI, 1.07-3.27; overall P = .035). When controlling for potential confounders such as gender, age, and smoking status, active asthma was associated with a higher odds of developing appendicitis compared with nonasthmatic patients (adjusted OR = 1.75; 95% CI, 0.99-3.11) whereas inactive asthma was not (overall P = .049). Tobacco smoke exposure within 3 months was associated with an increased risk of appendicitis (adjusted OR = 1.66; 95% CI, 1.02-2.69). Among asthma medications, leukotriene receptor antagonists reduced the risk of appendicitis (OR = 0.18; 95% CI, 0.04-0.74). CONCLUSIONS: Active asthma might be an unrecognized risk factor for appendicitis in children whereas a history of inactive asthma does not pose such risk. Further investigation exploring the underlying mechanisms is warranted.
OBJECTIVE: To assess whether asthma is associated with risk of appendicitis in children. METHODS: We used a population-based case-control study design using a comprehensive medical record review and predetermined criteria for appendicitis and asthma. All children (age younger than 18 years of age) who resided in Olmsted County, Minnesota, and developed appendicitis between 2006 and 2012 were matched to controls (1:1) with regard to birthday, gender, registration date, and index date. Asthma status was ascertained using predetermined criteria. Active (current) asthma was defined as the presence of asthma symptoms or asthma-related events (eg, medication use, clinic visits, emergency department, or hospitalization) within 1 year before the index date. Inactive asthma was defined as subjects without these events. A conditional logistic regression model was used. RESULTS: Among the 309 appendicitis cases identified, when stratified according to asthma status, active asthma was associated with significantly increased risk of appendicitis compared with inactive asthma (odds ratio [OR] = 2.48; 95% confidence interval [CI], 1.22-5.03) and to no asthma (OR = 1.88; 95% CI, 1.07-3.27; overall P = .035). When controlling for potential confounders such as gender, age, and smoking status, active asthma was associated with a higher odds of developing appendicitis compared with nonasthmatic patients (adjusted OR = 1.75; 95% CI, 0.99-3.11) whereas inactive asthma was not (overall P = .049). Tobacco smoke exposure within 3 months was associated with an increased risk of appendicitis (adjusted OR = 1.66; 95% CI, 1.02-2.69). Among asthma medications, leukotriene receptor antagonists reduced the risk of appendicitis (OR = 0.18; 95% CI, 0.04-0.74). CONCLUSIONS:Active asthma might be an unrecognized risk factor for appendicitis in children whereas a history of inactive asthma does not pose such risk. Further investigation exploring the underlying mechanisms is warranted.
Authors: Jennifer L St Sauver; Brandon R Grossardt; Barbara P Yawn; L Joseph Melton; Walter A Rocca Journal: Am J Epidemiol Date: 2011-03-23 Impact factor: 4.897
Authors: Young J Juhn; Hirohito Kita; Barbara P Yawn; Thomas G Boyce; Kwang H Yoo; Michaela E McGree; Amy L Weaver; Peter Wollan; Robert M Jacobson Journal: J Allergy Clin Immunol Date: 2008-09-13 Impact factor: 10.793
Authors: Duk Won Bang; Hyeon J Yang; Eell Ryoo; Majdi N Al-Hasan; Brian Lahr; Larry M Baddour; Barbara P Yawn; Young J Juhn Journal: BMJ Open Date: 2013-10-03 Impact factor: 2.692