Elaine Barros Ferreira1, Christiane Inocêncio Vasques2, Rafael Gadia3, Raymond Javan Chan4, Eliete Neves Silva Guerra2, Luis André Mezzomo5, Graziela De Luca Canto5, Paula Elaine Diniz Dos Reis2. 1. Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil. elaine.barrosf@gmail.com. 2. Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil. 3. Hospital Sírio Libanês, Asa Sul, Brasília, DF, Brazil. 4. FACN Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Queensland University of Technology, QLD, Kelvin Grove, 4059, Australia. 5. Federal University of Santa Catarina, Rua Engenheiro Agronômo Andrey Cristian Ferreira, Trindade, Florianópolis, Santa Catarina, Brazil.
Abstract
PURPOSE: The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis. METHODS: Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis. RESULTS: Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention. CONCLUSIONS: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.
PURPOSE: The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis. METHODS: Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis. RESULTS: Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention. CONCLUSIONS: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.
Entities:
Keywords:
Head and neck cancer; Radiodermatitis; Radiotherapy; Skin care
Authors: Elizabeth A Elliott; James R Wright; R Suzanne Swann; Felix Nguyen-Tân; Cristiane Takita; M Kara Bucci; Adam S Garden; Harold Kim; Eugen B Hug; Janice Ryu; Michael Greenberg; Jerrold P Saxton; Kian Ang; Lawrence Berk Journal: J Clin Oncol Date: 2006-05-01 Impact factor: 44.544
Authors: N Salvo; E Barnes; J van Draanen; E Stacey; G Mitera; D Breen; A Giotis; G Czarnota; J Pang; C De Angelis Journal: Curr Oncol Date: 2010-08 Impact factor: 3.677
Authors: V Ribet; S Salas; J M Levecq; L Bastit; M Alfonsi; G De Rauglaudre; B Talon; C Allavena; C Miot; J M Boisseau; P Faure Journal: Ann Dermatol Venereol Date: 2008-01 Impact factor: 0.777
Authors: An-Wen Chan; Jennifer M Tetzlaff; Douglas G Altman; Andreas Laupacis; Peter C Gøtzsche; Karmela Krleža-Jerić; Asbjørn Hróbjartsson; Howard Mann; Kay Dickersin; Jesse A Berlin; Caroline J Doré; Wendy R Parulekar; William S M Summerskill; Trish Groves; Kenneth F Schulz; Harold C Sox; Frank W Rockhold; Drummond Rennie; David Moher Journal: Ann Intern Med Date: 2013-02-05 Impact factor: 25.391
Authors: Mark S Nestor; Brian Berman; David Goldberg; Armand B Cognetta; Michael Gold; William Roth; Clay J Cockerell; Brad Glick Journal: J Clin Aesthet Dermatol Date: 2019-02-01
Authors: Julie Ryan Wolf; Charles E Heckler; Joseph J Guido; Anita R Peoples; Jennifer S Gewandter; Marilyn Ling; Vincent P Vinciguerra; Thomas Anderson; Lisa Evans; James Wade; Alice P Pentland; Gary R Morrow Journal: Support Care Cancer Date: 2017-12-01 Impact factor: 3.603
Authors: Julie Ryan Wolf; Jennifer S Gewandter; Javier Bautista; Charles E Heckler; Jon Strasser; Pawal Dyk; Thomas Anderson; Howard Gross; Tod Speer; Lindsey Dolohanty; Kevin Bylund; Alice P Pentland; Gary R Morrow Journal: Support Care Cancer Date: 2019-11-22 Impact factor: 3.603