Giuseppe Stabile1, Emanuele Bertaglia2, Carlo Pappone3, Sakis Themistoclakis4, Claudio Tondo5, Alessandro Zorzi2, Matteo Anselmino6. 1. Casa di Cura Mediterranea, Napoli. 2. Clinica Cardiologica, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari, Università degli Studi di Padova. 3. Casa di Cura Villa Maria Cecilia, Cotignola (RA)/. 4. Ospedale dell'Angelo, Mestre-Venezia. 5. Centro Cardiologico Monzino, Milano. 6. Divisione di Cardiologia, Dipartimento di Scienze Mediche, Università degli Studi di Torino, Italy.
Abstract
BACKGROUND: Despite catheter ablation (CA) has become an accepted treatment option for symptomatic, drug-resistant atrial fibrillation (AF), safety of this procedure continues to be cause for concern. OBJECTIVE: Aim of the present multicenter study was to assess the influence of age and gender on incidence and severity of early CA complications. METHODS: From January 1, 2011 to December 31, 2011, data from 2,323 consecutive patients who underwent CA (mean age 59.1+10.9; 72.3% male) for AF in 29 Italian centres were collected. All complications occurring to the patients from admission to 30th post-procedural day were recorded. RESULTS: Complications occurred in 94 patients (4.0%); of these 7 (0.30%) developed permanent sequelae. There was a significant trend toward a greater incidence of complications with increasing age-group. In particular, the incidence of complications was 35/1066 (3.3%) in patients <60 year-old vs 59/1257 (4.7%) in those > 60 year-old (p=0.03). All 7 patients with permanent sequeale were older than 60. Females had a higher incidence of complications both among younger [13/231 (5.6%) vs 22/915 (2.5%), p=0.02] and older patients [32/405 (7.9%) vs 27/739 (3.5%) p=0.001]. In subjects older than 60, 5/405 (1.2%) females and 2/176 (0.3%) males (p=0.04) suffered from permanent sequelae. CONCLUSIONS: Older patients and females are a subgroup at higher risk of complications during AF ablation. A particular care should be taken when performing CA in this clinical setting.
BACKGROUND: Despite catheter ablation (CA) has become an accepted treatment option for symptomatic, drug-resistant atrial fibrillation (AF), safety of this procedure continues to be cause for concern. OBJECTIVE: Aim of the present multicenter study was to assess the influence of age and gender on incidence and severity of early CA complications. METHODS: From January 1, 2011 to December 31, 2011, data from 2,323 consecutive patients who underwent CA (mean age 59.1+10.9; 72.3% male) for AF in 29 Italian centres were collected. All complications occurring to the patients from admission to 30th post-procedural day were recorded. RESULTS: Complications occurred in 94 patients (4.0%); of these 7 (0.30%) developed permanent sequelae. There was a significant trend toward a greater incidence of complications with increasing age-group. In particular, the incidence of complications was 35/1066 (3.3%) in patients <60 year-old vs 59/1257 (4.7%) in those > 60 year-old (p=0.03). All 7 patients with permanent sequeale were older than 60. Females had a higher incidence of complications both among younger [13/231 (5.6%) vs 22/915 (2.5%), p=0.02] and older patients [32/405 (7.9%) vs 27/739 (3.5%) p=0.001]. In subjects older than 60, 5/405 (1.2%) females and 2/176 (0.3%) males (p=0.04) suffered from permanent sequelae. CONCLUSIONS: Older patients and females are a subgroup at higher risk of complications during AF ablation. A particular care should be taken when performing CA in this clinical setting.
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