Literature DB >> 27956751

Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs.

Bereket Mochona1, Timothy Jackson1, DeCoria McCauley1, Elizabeth Mazzio2, Kinfe K Redda2.   

Abstract

Azomethine linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4-oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1H-NMR, 13C-NMR and elemental analysis. Evaluation for the cytotoxic activities In vitro against a panel of breast cancer cell lines (MDA-AB-231, BT-474 and Ishikawa cells) revealed that the pyrrole-benzimidazole hybrids are more potent than the pyrazolone and 1,3,4-oxadiazole hybrids in all cell lines. Compound (9) displayed promising cytotoxicity against BT-474 cell line with IC50 values, 7.7 µM.

Entities:  

Year:  2015        PMID： 27956751      PMCID： PMC5147751          DOI： 10.1002/jhet.2501

Source DB:  PubMed          Journal:  J Heterocycl Chem        ISSN： 0022-152X            Impact factor:   2.193


  26 in total

1.  Scavenging activity of aminoantipyrines against hydroxyl radical.

Authors:  Pedro M P Santos; Alexandra M M Antunes; João Noronha; Eduarda Fernandes; Abel J S C Vieira
Journal:  Eur J Med Chem       Date:  2010-02-02       Impact factor: 6.514

2.  The new era of 1,2,4-oxadiazoles.

Authors:  Andrea Pace; Paola Pierro
Journal:  Org Biomol Chem       Date:  2009-09-16       Impact factor: 3.876

3.  Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.

Authors:  Bhaskar Gopishetty; Suhong Zhang; Prashant S Kharkar; Tamara Antonio; Maarten Reith; Aloke K Dutta
Journal:  Bioorg Med Chem       Date:  2013-04-01       Impact factor: 3.641

4.  Synthesis of novel 1,3,4-oxadiazole derivatives as potential antimicrobial agents.

Authors:  Rakesh Chawla; Anshu Arora; Manoj Kumar Parameswaran; Prabodh Chan; Der Sharma; Sukumar Michael; Thengungal Kochupappy Ravi
Journal:  Acta Pol Pharm       Date:  2010 May-Jun       Impact factor: 0.330

Review 5.  Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents.

Authors:  Monika Gaba; Sarbjot Singh; Chander Mohan
Journal:  Eur J Med Chem       Date:  2014-02-18       Impact factor: 6.514

Review 6.  Recent updates on biological activities of oxadiazoles.

Authors:  Rikta Saha; Omprakash Tanwar; Akranth Marella; M Mumtaz Alam; Mymoona Akhter
Journal:  Mini Rev Med Chem       Date:  2013-06       Impact factor: 3.862

7.  Design, synthesis and antimicrobial activities of some azole derivatives.

Authors:  Serap Basoglu; Meltem Yolal; Serpil Demirci; Neslihan Demirbas; Hakan Bektas; Sengul Alpay Karaoglu
Journal:  Acta Pol Pharm       Date:  2013 Mar-Apr       Impact factor: 0.330

8.  Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.

Authors:  Xue-Quan Wang; Lan-Xiang Liu; Yan Li; Cheng-Jun Sun; Wen Chen; Liang Li; Hong-Bin Zhang; Xiao-Dong Yang
Journal:  Eur J Med Chem       Date:  2013-01-03       Impact factor: 6.514

9.  Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors.

Authors:  Aloke K Dutta; Sylesh K Venkataraman; Xiang-Shu Fei; Rohit Kolhatkar; Shijun Zhang; Maarten E A Reith
Journal:  Bioorg Med Chem       Date:  2004-08-15       Impact factor: 3.641

Review 10.  1,3,4-oxadiazole derivatives as potential biological agents.

Authors:  Juan Sun; Jigar A Makawana; Hai-Liang Zhu
Journal:  Mini Rev Med Chem       Date:  2013-10       Impact factor: 3.862
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  1 in total

1.  Improving Representation of Underrepresented Minority (URM) Students in Oncology Biomedical Research Workforce: Outcome Evaluation from the ReTOOL Program.

Authors:  Folakemi T Odedina; Linda S Behar-Horenstein; Parisa Fathi; Ernest Kaninjing; Jennifer Nguyen; Nissa Askins; R Renee Reams; Bereket Mochona; Adaora Ezeani; Debra Lyon; Kayanna Jacobs; Michael Maduka
Journal:  J Cancer Educ       Date:  2022-02       Impact factor: 1.771
  1 in total

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