Azomethine linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4-oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1H-NMR, 13C-NMR and elemental analysis. Evaluation for the cytotoxic activities In vitro against a panel of breast cancer cell lines (MDA-AB-231, BT-474 and Ishikawa cells) revealed that the pyrrole-benzimidazole hybrids are more potent than the pyrazolone and 1,3,4-oxadiazole hybrids in all cell lines. Compound (9) displayed promising cytotoxicity against BT-474 cell line with IC50 values, 7.7 µM.
Azomethine ln class="Chemical">inked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4-oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1H-NMR, 13C-NMR and elemental analysis. Evaluation for the cytotoxic activities In vitro against a panel of breast cancer cell lines (MDA-AB-231, BT-474 and Ishikawa cells) revealed that the pyrrole-benzimidazole hybrids are more potent than the pyrazolone and 1,3,4-oxadiazole hybrids in all cell lines. Compound (9) displayed promising cytotoxicity against BT-474 cell line with IC50 values, 7.7 µM.
Authors: Pedro M P Santos; Alexandra M M Antunes; João Noronha; Eduarda Fernandes; Abel J S C Vieira Journal: Eur J Med Chem Date: 2010-02-02 Impact factor: 6.514
Authors: Folakemi T Odedina; Linda S Behar-Horenstein; Parisa Fathi; Ernest Kaninjing; Jennifer Nguyen; Nissa Askins; R Renee Reams; Bereket Mochona; Adaora Ezeani; Debra Lyon; Kayanna Jacobs; Michael Maduka Journal: J Cancer Educ Date: 2022-02 Impact factor: 1.771