Literature DB >> 27951484

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period.

Wasim Akhtar1, Mohemmed Faraz Khan1, Garima Verma1, M Shaquiquzzaman1, M A Rizvi2, Syed Hassan Mehdi2, Mymoona Akhter1, M Mumtaz Alam3.   

Abstract

Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained considerable attention in the field of contemporary medicinal chemistry. The moiety is of substantial importance because of its wide array of pharmacological activities. This nitrogen containing heterocycle is a part of a number of therapeutically used agents. Moreover, a number of patents concerning this moiety in the last few years further highlight its worth. The present review covers the recent work published by scientists across the globe during last five years.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Anti-cancer; Anti-inflammatory and analgesic; Antiviral; Benzimidazole; Biological activity; Heterocyclic

Mesh:

Substances:

Year:  2016        PMID: 27951484     DOI: 10.1016/j.ejmech.2016.12.010

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  23 in total

1.  A practical multi-step synthesis of ethyl N-functionalized [Formula: see text]-amino benzimidazole acrylate derivatives as promising cytotoxic agents.

Authors:  Christelle N'Ta Ambeu; Rémy Le Guével; Anne Corlu; Janat Akhanovna Mamyrbekova; Jean-Pierre Bazureau
Journal:  Mol Divers       Date:  2018-04-05       Impact factor: 2.943

2.  PTSA-catalyzed selective synthesis and antibacterial evaluation of 1,2-disubstituted benzimidazoles.

Authors:  Jiaxu Fu; Yuandong Yue; Kejun Liu; Shuang Wang; Yiliang Zhang; Qing Su; Qiang Gu; Feng Lin; Yumin Zhang
Journal:  Mol Divers       Date:  2022-06-19       Impact factor: 2.943

3.  Benzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment.

Authors:  Aman Ullah; Lina Tariq Al Kury; Yusuf S Althobaiti; Tahir Ali; Fawad ALi Shah
Journal:  J Inflamm Res       Date:  2022-07-11

4.  Design, synthesis and biological evaluation of benzimidazole-rhodanine conjugates as potent topoisomerase II inhibitors.

Authors:  Penghui Li; Wenjin Zhang; Hong Jiang; Yongliang Li; Changzhi Dong; Huixiong Chen; Kun Zhang; Zhiyun Du
Journal:  Medchemcomm       Date:  2018-06-02       Impact factor: 3.597

5.  Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors.

Authors:  Wei Zhou; Wenjin Zhang; Yi Peng; Zhi-Hong Jiang; Lanyue Zhang; Zhiyun Du
Journal:  Molecules       Date:  2020-07-12       Impact factor: 4.411

6.  Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies.

Authors:  Afzal Hussain; Mohamed Fahad AlAjmi; Md Tabish Rehman; Samira Amir; Fohad Mabood Husain; Ali Alsalme; Maqsood Ahmad Siddiqui; Abdulaziz A AlKhedhairy; Rais Ahmad Khan
Journal:  Sci Rep       Date:  2019-03-27       Impact factor: 4.379

7.  Crystal structure of bis-[2-(1H-benzimidazol-2-yl-κN 3)aniline-κN]bis-(nitrato-κO)cadmium(II).

Authors:  Yongtae Kim; Sung Kwon Kang
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-09-12

8.  Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration.

Authors:  Muhammad Imran; Lina Tariq Al Kury; Humaira Nadeem; Fawad Ali Shah; Muzaffar Abbas; Shagufta Naz; Arif-Ullah Khan; Shupeng Li
Journal:  Biomolecules       Date:  2020-01-08

9.  Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.

Authors:  Andrea Bistrović; Luka Krstulović; Ivana Stolić; Domagoj Drenjančević; Jasminka Talapko; Martin C Taylor; John M Kelly; Miroslav Bajić; Silvana Raić-Malić
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

10.  Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents.

Authors:  Fawzia Faleh Al-Blewi; Meshal A Almehmadi; Mohamed Reda Aouad; Sanaa K Bardaweel; Pramod K Sahu; Mouslim Messali; Nadjet Rezki; El Sayed H El Ashry
Journal:  Chem Cent J       Date:  2018-11-01       Impact factor: 4.215

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