Literature DB >> 27940091

Pathogenesis of NEC: Role of the innate and adaptive immune response.

Timothy L Denning1, Amina M Bhatia2, Andrea F Kane3, Ravi M Patel3, Patricia W Denning4.   

Abstract

Necrotizing enterocolitis (NEC) is a devastating disease in premature infants with high case fatality and significant morbidity among survivors. Immaturity of intestinal host defenses predisposes the premature infant gut to injury. An abnormal bacterial colonization pattern with a deficiency of commensal bacteria may lead to a further breakdown of these host defense mechanisms, predisposing the infant to NEC. Here, we review the role of the innate and adaptive immune system in the pathophysiology of NEC.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Necrotizing enterocolitis; adaptive intestinal immunity; innate intestinal immunity; pathogenesis

Mesh：

Year:  2016        PMID： 27940091      PMCID： PMC5484641          DOI： 10.1053/j.semperi.2016.09.014

Source DB:  PubMed          Journal:  Semin Perinatol        ISSN： 0146-0005            Impact factor:   3.300


  243 in total

1.  Intestinal permeability in relation to birth weight and gestational and postnatal age.

Authors:  R M van Elburg; W P F Fetter; C M Bunkers; H S A Heymans
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2003-01       Impact factor: 5.747

Review 2.  Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.

Authors:  Nita H Salzman; Mark A Underwood; Charles L Bevins
Journal:  Semin Immunol       Date:  2007-05-07       Impact factor: 11.130

3.  Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.

Authors:  Misty Good; Richard H Siggers; Chhinder P Sodhi; Amin Afrazi; Feras Alkhudari; Charlotte E Egan; Matthew D Neal; Ibrahim Yazji; Hongpeng Jia; Joyce Lin; Maria F Branca; Congrong Ma; Thomas Prindle; Zachary Grant; Sapana Shah; Dennis Slagle; Jose Paredes; John Ozolek; George K Gittes; David J Hackam
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-25       Impact factor: 11.205

4.  Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

Authors:  Timothy L Denning; Brian A Norris; Oscar Medina-Contreras; Santhakumar Manicassamy; Duke Geem; Rajat Madan; Christopher L Karp; Bali Pulendran
Journal:  J Immunol       Date:  2011-06-10       Impact factor: 5.422

5.  Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis.

Authors:  Julia Arciero; G Bard Ermentrout; Richard Siggers; Amin Afrazi; David Hackam; Yoram Vodovotz; Jonathan Rubin
Journal:  J Theor Biol       Date:  2012-12-10       Impact factor: 2.691

6.  Recruitment of dendritic cells is responsible for intestinal epithelial damage in the pathogenesis of necrotizing enterocolitis by Cronobacter sakazakii.

Authors:  Claudia N Emami; Rahul Mittal; Larry Wang; Henri R Ford; Nemani V Prasadarao
Journal:  J Immunol       Date:  2011-05-06       Impact factor: 5.422

7.  Decreased interleukin-10 production by neonatal monocytes and T cells: relationship to decreased production and expression of tumor necrosis factor-alpha and its receptors.

Authors:  S Chheda; K H Palkowetz; R Garofalo; D K Rassin; A S Goldman
Journal:  Pediatr Res       Date:  1996-09       Impact factor: 3.756

8.  Epidermal growth factor reduces hepatic sequelae in experimental necrotizing enterocolitis.

Authors:  Melissa D Halpern; Hana Holubec; Jessica A Clark; Tara A Saunders; Catherine S Williams; Katerina Dvorak; Bohuslav Dvorak
Journal:  Biol Neonate       Date:  2005-11-29

9.  Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors.

Authors:  Erika C Claud; Tor Savidge; W Allen Walker
Journal:  Pediatr Res       Date:  2003-03       Impact factor: 3.756

10.  Transforming growth factor-beta 1, macrophage inflammatory protein-1 alpha, and interleukin-8 gene expression is lower in stimulated human neonatal compared with adult mononuclear cells.

Authors:  M Chang; Y Suen; S M Lee; D Baly; J S Buzby; E Knoppel; S Wolpe; M S Cairo
Journal:  Blood       Date:  1994-07-01       Impact factor: 22.113
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  19 in total

Review 1.  Probiotics and necrotizing enterocolitis.

Authors:  Ravi Mangal Patel; Mark A Underwood
Journal:  Semin Pediatr Surg       Date:  2017-11-06       Impact factor: 2.754

2.  Butyrate induces development-dependent necrotizing enterocolitis-like intestinal epithelial injury via necroptosis.

Authors:  Kewei Wang; Guo-Zhong Tao; Fereshteh Salimi-Jazi; Po-Yu Lin; Zhen Sun; Bo Liu; Tiffany Sinclair; Mirko Mostaghimi; James Dunn; Karl G Sylvester
Journal:  Pediatr Res       Date:  2022-10-06       Impact factor: 3.953

Review 3.  IL-17 in neonatal health and disease.

Authors:  Shelley M Lawrence; Jessica Lauren Ruoss; James L Wynn
Journal:  Am J Reprod Immunol       Date:  2017-12-15       Impact factor: 3.886

4.  Impact and Clinical Implications of Prematurity on Adaptive Immune Development.

Authors:  Emma Idzikowski; Thomas J Connors
Journal:  Curr Pediatr Rep       Date:  2020-10-26

Review 5.  Advances in our understanding of the molecular pathogenesis of necrotizing enterocolitis.

Authors:  Xue Cai; Alena Golubkova; Catherine J Hunter
Journal:  BMC Pediatr       Date:  2022-04-25       Impact factor: 2.567

6.  Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study.

Authors:  Margareta Ahle; Peder Drott; Anders Elfvin; Roland E Andersson
Journal:  PLoS One       Date:  2018-03-23       Impact factor: 3.240

7.  Development of a human milk concentrate with human milk lyophilizate for feeding very low birth weight preterm infants: A preclinical experimental study.

Authors:  Mariana M Oliveira; Davi C Aragon; Vanessa S Bomfim; Tânia M B Trevilato; Larissa G Alves; Anália R Heck; Francisco E Martinez; José S Camelo
Journal:  PLoS One       Date:  2019-02-20       Impact factor: 3.240

Review 8.  Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis.

Authors:  Kewei Wang; Guozhong Tao; Zhen Sun; Karl G Sylvester
Journal:  Gastroenterol Res Pract       Date:  2019-04-22       Impact factor: 2.260

9.  CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants.

Authors:  Oluwabunmi O Olaloye; Peng Liu; Jessica M Toothaker; Blake T McCourt; Collin C McCourt; Jenny Xiao; Erica Prochaska; Spenser Shaffer; Lael Werner; Jordan Gringauz; Misty Good; Jeffrey D Goldsmith; Xiaojing An; Fujing Wang; Scott B Snapper; Dror Shouval; Kong Chen; George Tseng; Liza Konnikova
Journal:  J Exp Med       Date:  2021-07-16       Impact factor: 14.307

10.  Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation.

Authors:  Yu-Mei He; Xing Li; Michela Perego; Yulia Nefedova; Andrew V Kossenkov; Erik A Jensen; Valerian Kagan; Yu-Feng Liu; Shu-Yu Fu; Qing-Jian Ye; Yan-Hong Zhou; Lai Wei; Dmitry I Gabrilovich; Jie Zhou
Journal:  Nat Med       Date:  2018-01-15       Impact factor: 53.440
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