OBJECTIVE: To determine the relation between intestinal permeability and birth weight, gestational age, postnatal age, and perinatal risk factors in neonates. STUDY DESIGN: Intestinal permeability was measured by the sugar absorption test within two days of birth and three to six days later in preterm and healthy term infants. In the sugar absorption test, the urinary lactulose/mannitol ratio is measured after oral ingestion of a solution (375 mosm) of lactulose and mannitol. RESULTS: A first sugar absorption test was performed in 116 preterm (26-36 weeks gestation) and 16 term infants. A second test was performed in 102 preterm and nine term infants. In the preterm infants, the lactulose/mannitol ratio was not related to gestational age (r = -0.09, p = 0.32) or birth weight (r = 0.07, p = 0.43). The median lactulose/mannitol ratio was higher if measured less than two days after birth than when measured three to six days later (0.427 and 0.182 respectively, p<0.001). The lactulose/mannitol ratio was higher in preterm infants than term infants if measured within the first 2 days of life (0.404 and 0.170 respectively, p < 0.001), but not different three to six days later (0.182 and 0.123 respectively, p = 0.08). In multiple regression analysis of perinatal risk factors, only umbilical arterial pH correlated with the lactulose/mannitol ratio in preterm infants less than 2 days of age (T = -1.98, p = 0.05). CONCLUSIONS: In preterm infants (26-36 weeks gestation), intestinal permeability is not related to gestational age or birth weight but is higher during the first 2 days of life than three to six days later. It is higher in preterm infants than in healthy term infants only if measured within two days of birth. This suggests rapid postnatal adaptation of the small intestine in preterm infants.
OBJECTIVE: To determine the relation between intestinal permeability and birth weight, gestational age, postnatal age, and perinatal risk factors in neonates. STUDY DESIGN: Intestinal permeability was measured by the sugar absorption test within two days of birth and three to six days later in preterm and healthy term infants. In the sugar absorption test, the urinary lactulose/mannitol ratio is measured after oral ingestion of a solution (375 mosm) of lactulose and mannitol. RESULTS: A first sugar absorption test was performed in 116 preterm (26-36 weeks gestation) and 16 term infants. A second test was performed in 102 preterm and nine term infants. In the preterm infants, the lactulose/mannitol ratio was not related to gestational age (r = -0.09, p = 0.32) or birth weight (r = 0.07, p = 0.43). The median lactulose/mannitol ratio was higher if measured less than two days after birth than when measured three to six days later (0.427 and 0.182 respectively, p<0.001). The lactulose/mannitol ratio was higher in preterm infants than term infants if measured within the first 2 days of life (0.404 and 0.170 respectively, p < 0.001), but not different three to six days later (0.182 and 0.123 respectively, p = 0.08). In multiple regression analysis of perinatal risk factors, only umbilical arterial pH correlated with the lactulose/mannitol ratio in preterm infants less than 2 days of age (T = -1.98, p = 0.05). CONCLUSIONS: In preterm infants (26-36 weeks gestation), intestinal permeability is not related to gestational age or birth weight but is higher during the first 2 days of life than three to six days later. It is higher in preterm infants than in healthy term infants only if measured within two days of birth. This suggests rapid postnatal adaptation of the small intestine in preterm infants.
Authors: Ellen V Rouwet; Erik Heineman; Wim A Buurman; Gerben ter Riet; Graham Ramsay; Carlos E Blanco Journal: Pediatr Res Date: 2002-01 Impact factor: 3.756
Authors: C E Harris; R D Griffiths; N Freestone; D Billington; S T Atherton; R R Macmillan Journal: Intensive Care Med Date: 1992 Impact factor: 17.440
Authors: R M van Elburg; A van den Berg; C M Bunkers; R A van Lingen; E W A Smink; J van Eyck; W P F Fetter Journal: Arch Dis Child Fetal Neonatal Ed Date: 2004-07 Impact factor: 5.747
Authors: Julie Tomas; Céline Mulet; Azadeh Saffarian; Jean-Baptiste Cavin; Robert Ducroc; Béatrice Regnault; Chek Kun Tan; Kalina Duszka; Rémy Burcelin; Walter Wahli; Philippe J Sansonetti; Thierry Pédron Journal: Proc Natl Acad Sci U S A Date: 2016-09-16 Impact factor: 11.205
Authors: Timothy L Denning; Amina M Bhatia; Andrea F Kane; Ravi M Patel; Patricia W Denning Journal: Semin Perinatol Date: 2016-12-09 Impact factor: 3.300
Authors: Akhil Maheshwari; Ashish R Kurundkar; Sadiq S Shaik; David R Kelly; Yolanda Hartman; Wei Zhang; Reed Dimmitt; Shehzad Saeed; David A Randolph; Charles Aprahamian; Geeta Datta; Robin K Ohls Journal: Am J Physiol Gastrointest Liver Physiol Date: 2009-05-14 Impact factor: 4.052