Sumitaka Kobayashi1, Fumihiro Sata2, Chihiro Miyashita1, Seiko Sasaki3, Susumu Ban4, Atsuko Araki1, Houman Goudarzi1, Jumboku Kajiwara5, Takashi Todaka6, Reiko Kishi7. 1. Hokkaido University Center for Environmental and Health Sciences, North-12, West-7, Kita-ku, Sapporo 060-0812, Japan. 2. Hokkaido University Center for Environmental and Health Sciences, North-12, West-7, Kita-ku, Sapporo 060-0812, Japan; Health Center, Chuo University, 42-8, Ichigaya-Hommura-cho, Shinjuku-ku, Tokyo 162-8473, Japan. 3. Department of Public Health, Hokkaido University Graduate School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan. 4. Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3, Minami-Tamagaki-cho, Suzuka 513-8670, Japan. 5. Fukuoka Institute of Health and Environmental Sciences, Mukaizano 39, Dazaifu 818-0135, Japan. 6. Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. 7. Hokkaido University Center for Environmental and Health Sciences, North-12, West-7, Kita-ku, Sapporo 060-0812, Japan. Electronic address: rkishi@med.hokudai.ac.jp.
Abstract
OBJECTIVES: We investigated the effects of maternal polymorphisms in 3 genes encoding dioxin-metabolizing enzymes in relation to prenatal dioxin levels on infant birth size in Japan. METHODS: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G>A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu 1 (GSTM1; Non-null/null) in 421 participants using multiple linear regression models. RESULTS: In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345g (95% confidence interval: -584, -105). CONCLUSIONS: We observed adverse effects of maternal GSTM1 null genotype on birth weight in the presence of dioxins exposure during pregnancy.
OBJECTIVES: We investigated the effects of maternal polymorphisms in 3 genes encoding dioxin-metabolizing enzymes in relation to prenatal dioxin levels on infant birth size in Japan. METHODS: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G>A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu 1 (GSTM1; Non-null/null) in 421 participants using multiple linear regression models. RESULTS: In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345g (95% confidence interval: -584, -105). CONCLUSIONS: We observed adverse effects of maternal GSTM1 null genotype on birth weight in the presence of dioxins exposure during pregnancy.