Lin Chen1, Song Zhao1, Feng Niu2, Gui-Bin Bi1. 1. Department of Spine Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, PR China. 2. Department of Spine Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, PR China. Electronic address: niufeng168@hotmail.com.
Abstract
BACKGROUND: Studies that have investigated the association between vitamin D receptor (VDR) gene polymorphisms and intervertebral disc degeneration (IDD) have yielded inconsistent results. METHODS: To investigate the association between VDR gene polymorphisms and IDD, a systematic literature search for relevant published studies was performed on PubMed, Embase, Web of Science, Cochrane library, Wan-Fang, and CNKI databases. A random effects model was used for heterogeneous data; while a fixed effect model was used for homogenous data. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association. RESULTS: We observed no association between VDR FokI, TaqI-ApaI polymorphisms and IDD. However, on subgroup analysis by ethnicity, VDR FokI mutation was associated with a significantly lower risk for IDD [dominant model: OR = 0.78, 95% CI = 0.65-0.93; heterozygote model: OR = 0.76, 95% CI = 0.63-0.92; allele model: OR = 0.86, 95% CI = 0.75-0.98] among Caucasians. CONCLUSION: These results suggest that the VDR FokI polymorphism may be associated with IDD among Caucasians. However, the association between VDR TaqI-ApaI polymorphisms and IDD in Asians is still not clear. Further well-designed studies are needed to arrive at a definitive conclusion.
BACKGROUND: Studies that have investigated the association between vitamin D receptor (VDR) gene polymorphisms and intervertebral disc degeneration (IDD) have yielded inconsistent results. METHODS: To investigate the association between VDR gene polymorphisms and IDD, a systematic literature search for relevant published studies was performed on PubMed, Embase, Web of Science, Cochrane library, Wan-Fang, and CNKI databases. A random effects model was used for heterogeneous data; while a fixed effect model was used for homogenous data. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association. RESULTS: We observed no association between VDR FokI, TaqI-ApaI polymorphisms and IDD. However, on subgroup analysis by ethnicity, VDR FokI mutation was associated with a significantly lower risk for IDD [dominant model: OR = 0.78, 95% CI = 0.65-0.93; heterozygote model: OR = 0.76, 95% CI = 0.63-0.92; allele model: OR = 0.86, 95% CI = 0.75-0.98] among Caucasians. CONCLUSION: These results suggest that the VDR FokI polymorphism may be associated with IDD among Caucasians. However, the association between VDR TaqI-ApaI polymorphisms and IDD in Asians is still not clear. Further well-designed studies are needed to arrive at a definitive conclusion.
Authors: Paola De Luca; Laura de Girolamo; Carlotta Perucca Orfei; Marco Viganò; Riccardo Cecchinato; Marco Brayda-Bruno; Alessandra Colombini Journal: Int J Mol Sci Date: 2018-07-09 Impact factor: 5.923
Authors: Sabina Cauci; Marco Viganò; Laura de Girolamo; Paola De Luca; Carlotta Perucca Orfei; Giuseppe Banfi; Giovanni Lombardi; Marco Brayda-Bruno; Alessandra Colombini Journal: Int J Mol Sci Date: 2017-09-29 Impact factor: 5.923