Sarah Tatencloux1, Véronique Mosseri2, Solesne Papillard-Maréchal1, Bettina Mesples3, Beatrice Pellegrino4, Marie Belloy5, Irene Jimènez6, Nathalie Algret2, Dominique Levy6, Jean Michon6, Daniel Orbach7. 1. AP-HP, hôpital Ambroise-Paré, service de pédiatrie générale, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. 2. Institut Curie, département de biostatistiques, 26, rue d'Ulm, 75005 Paris, France. 3. AP-HP, hôpital Louis-Mourier, service de pédiatrie, 278, rue des Renouillers, 92701 Colombes, France. 4. Centre hospitalier intercommunal de Poissy-Saint-Germain en Laye, service de pédiatrie, 10, rue Champ-Gaillard, 78300 Poissy, France. 5. Centre hospitalier Robert-Ballanger, service de pédiatrie, boulevard Robert-Ballanger, 93600 Aulnay-sous-Bois, France. 6. Institut Curie, département de pédiatrie, adolescents, jeunes adultes, 26, rue d'Ulm, 75005 Paris, France. 7. Institut Curie, département de pédiatrie, adolescents, jeunes adultes, 26, rue d'Ulm, 75005 Paris, France. Electronic address: daniel.orbach@curie.fr.
Abstract
OBJECTIVE: to describe medical care pathways between first symptoms and first oncologic consultation in children and adolescents with solid cancers in order to analyze a possible relationship between delayed diagnosis and its potential consequences. METHODS: Retrospective study on patients aged less than 25 years at first consultation in the oncology department of pediatric, adolescent and young adult in Institut Curie during one year. Were collected data on cancer characteristics, components of care pathways, and sociodemographic parents' characteristics. RESULTS: Hundred and six patients were selected, with median age of 6 years. Most represented tumor was low-grade cerebral tumor (17.0%). Pain was the most frequent type of disorder observed as first sign (34.3% of patients). First signs were unspecific in only 27.6% of cases. Most patients were first seen by a general practitioner (29.3%). Median total time to diagnosis was one month [ranges: 0-64]. Median number of consultations before referral to oncology expert was 2 [0-7]. Retrospective analysis found a possible delayed diagnosis in 44.3% of patients, with potential vital and functional risks estimated respectively at 14.1 and 20.7% of overall population. Time to diagnosis was shorter if father was of foreign nationality vs. French (34 days vs. 72 days, P<0.05), and longer if parents were separated (74.5 days vs. 42.5 days, P<0.03). CONCLUSIONS: Overall time to diagnosis is quite fast, even if first signs of pediatric cancers are very polymorphic. Some medical and sociodemographic factors could influence characteristics of care pathways.
OBJECTIVE: to describe medical care pathways between first symptoms and first oncologic consultation in children and adolescents with solid cancers in order to analyze a possible relationship between delayed diagnosis and its potential consequences. METHODS: Retrospective study on patients aged less than 25 years at first consultation in the oncology department of pediatric, adolescent and young adult in Institut Curie during one year. Were collected data on cancer characteristics, components of care pathways, and sociodemographic parents' characteristics. RESULTS: Hundred and six patients were selected, with median age of 6 years. Most represented tumor was low-grade cerebral tumor (17.0%). Pain was the most frequent type of disorder observed as first sign (34.3% of patients). First signs were unspecific in only 27.6% of cases. Most patients were first seen by a general practitioner (29.3%). Median total time to diagnosis was one month [ranges: 0-64]. Median number of consultations before referral to oncology expert was 2 [0-7]. Retrospective analysis found a possible delayed diagnosis in 44.3% of patients, with potential vital and functional risks estimated respectively at 14.1 and 20.7% of overall population. Time to diagnosis was shorter if father was of foreign nationality vs. French (34 days vs. 72 days, P<0.05), and longer if parents were separated (74.5 days vs. 42.5 days, P<0.03). CONCLUSIONS: Overall time to diagnosis is quite fast, even if first signs of pediatric cancers are very polymorphic. Some medical and sociodemographic factors could influence characteristics of care pathways.
Authors: Robin Grant; Therese Dowswell; Eve Tomlinson; Paul M Brennan; Fiona M Walter; Yoav Ben-Shlomo; David William Hunt; Helen Bulbeck; Ashleigh Kernohan; Tomos Robinson; Theresa A Lawrie Journal: Cochrane Database Syst Rev Date: 2020-09-04