Literature DB >> 27933565

KSHV strategies for host dsDNA sensing machinery.

Hang Gao1, Yanyan Song2, Chengrong Liu3, Qiming Liang4.   

Abstract

The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi's Sarcoma-associated Herpesvirus (KSHV) and their contributions to KSHV life cycles.

Entities:  

Keywords:  Kaposi’s sarcoma-associated herpesvirus (KSHV); autophagy; cyclic GMP-AMP synthase (cGAS); evasion strategies; innate immune response; interferon

Mesh：

Substances：

Year:  2016        PMID： 27933565      PMCID： PMC8193444          DOI： 10.1007/s12250-016-3877-3

Source DB:  PubMed          Journal:  Virol Sin        ISSN： 1995-820X            Impact factor:   4.327


  54 in total

Review 1.  Innate recognition of viruses.

Authors:  Andreas Pichlmair; Caetano Reis e Sousa
Journal:  Immunity       Date:  2007-09       Impact factor: 31.745

2.  Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

Authors:  Kohichi Matsunaga; Tatsuya Saitoh; Keisuke Tabata; Hiroko Omori; Takashi Satoh; Naoki Kurotori; Ikuko Maejima; Kanae Shirahama-Noda; Tohru Ichimura; Toshiaki Isobe; Shizuo Akira; Takeshi Noda; Tamotsu Yoshimori
Journal:  Nat Cell Biol       Date:  2009-03-08       Impact factor: 28.824

Review 3.  Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis.

Authors:  Denis Avey; Brittany Brewers; Fanxiu Zhu
Journal:  Virol Sin       Date:  2015-04-23       Impact factor: 4.327

4.  Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.

Authors:  M Mutocheluh; L Hindle; C Aresté; S A Chanas; L M Butler; K Lowry; K Shah; D J Evans; D J Blackbourn
Journal:  J Gen Virol       Date:  2011-06-22       Impact factor: 3.891

5.  Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Authors:  Qiming Liang; Gil Ju Seo; Youn Jung Choi; Mi-Jeong Kwak; Jianning Ge; Mary A Rodgers; Mude Shi; Benjamin J Leslie; Karl-Peter Hopfner; Taekjip Ha; Byung-Ha Oh; Jae U Jung
Journal:  Cell Host Microbe       Date:  2014-02-12       Impact factor: 21.023

6.  Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Authors:  Lijun Sun; Jiaxi Wu; Fenghe Du; Xiang Chen; Zhijian J Chen
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

7.  STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.

Authors:  Hiroki Ishikawa; Zhe Ma; Glen N Barber
Journal:  Nature       Date:  2009-09-23       Impact factor: 49.962

8.  Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression.

Authors:  R Sun; S F Lin; K Staskus; L Gradoville; E Grogan; A Haase; G Miller
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

9.  Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression.

Authors:  Sylvain Lefort; Anton Soucy-Faulkner; Nathalie Grandvaux; Louis Flamand
Journal:  J Virol       Date:  2007-07-25       Impact factor: 5.103

Review 10.  Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.

Authors:  Chengyu Liang; Jong-Soo Lee; Jae U Jung
Journal:  Semin Cancer Biol       Date:  2008-10-02       Impact factor: 15.707
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  1 in total

1.  Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus.

Authors:  Qiming Liang; Dahai Wei; Brian Chung; Kevin F Brulois; Changrun Guo; Shupeng Dong; Shou-Jiang Gao; Pinghui Feng; Chengyu Liang; Jae U Jung
Journal:  J Virol       Date:  2018-01-30       Impact factor: 5.103
  1 in total

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