Literature DB >> 21697347

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.

M Mutocheluh1, L Hindle1, C Aresté1, S A Chanas1, L M Butler2,1, K Lowry3, K Shah4, D J Evans3, D J Blackbourn5,1.   

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type I interferon (IFN) induction. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of vIRF-2 activity. The biological significance of vIRF-2 inhibition of ISGF-3 was demonstrated by vIRF-2-mediated rescue of the replication of the IFN-sensitive virus encephalomyocarditis virus. This study provides both a mechanism and evidence for KSHV vIRF-2-mediated suppression of the consequences of type 1 IFN-induced signalling.

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Year:  2011        PMID： 21697347     DOI： 10.1099/vir.0.034322-0

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  22 in total

1.  A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response.

Authors:  Gabriela Morin; Bridget A Robinson; Kelsey S Rogers; Scott W Wong
Journal:  J Virol       Date:  2015-05-13       Impact factor: 5.103

2.  KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production.

Authors:  Sung-Woo Hwang; DongIk Kim; Jae U Jung; Hye-Ra Lee
Journal:  Biochem Biophys Res Commun       Date:  2017-03-22       Impact factor: 3.575

Review 3.  Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.

Authors:  Marni S Crow; Krystal K Lum; Xinlei Sheng; Bokai Song; Ileana M Cristea
Journal:  Crit Rev Biochem Mol Biol       Date:  2016-09-21       Impact factor: 8.250

4.  Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway.

Authors:  Gavin Golas; Seung Jin Jang; Nenavath Gopal Naik; Juan D Alonso; Bernadett Papp; Zsolt Toth
Journal:  Virology       Date:  2019-12-30       Impact factor: 3.616

Review 5.  Multi-step regulation of innate immune signaling by Kaposi's sarcoma-associated herpesvirus.

Authors:  Hye-Ra Lee; Rina Amatya; Jae U Jung
Journal:  Virus Res       Date:  2015-03-19       Impact factor: 3.303

Review 6.  KSHV strategies for host dsDNA sensing machinery.

Authors:  Hang Gao; Yanyan Song; Chengrong Liu; Qiming Liang
Journal:  Virol Sin       Date:  2016-12-05       Impact factor: 4.327

7.  The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3.

Authors:  Sarah R Jacobs; Sean M Gregory; John A West; Amy C Wollish; Christopher L Bennett; David J Blackbourn; Mark T Heise; Blossom Damania
Journal:  J Virol       Date:  2012-10-31       Impact factor: 5.103

8.  Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor.

Authors:  Haidai Hu; Jiazhen Dong; Deguang Liang; Zengqiang Gao; Lei Bai; Rui Sun; Hao Hu; Heng Zhang; Yuhui Dong; Ke Lan
Journal:  J Virol       Date:  2015-11-04       Impact factor: 5.103

Review 9.  The Dynamic Interface of Viruses with STATs.

Authors:  Angela R Harrison; Gregory W Moseley
Journal:  J Virol       Date:  2020-10-27       Impact factor: 5.103

Review 10.  Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer.

Authors:  Petra Baresova; Paula M Pitha; Barbora Lubyova
Journal:  J Virol       Date:  2013-06-19       Impact factor: 5.103
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