| Literature DB >> 27933436 |
Abstract
Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L-1) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L-1). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A. terreus. A number of recombinant microorganisms have been developed in an effort to overproduce it. IA is used as a monomer for production of superabsorbent polymer, resins, plastics, paints, and synthetic fibers. Its applications as a platform chemical are highlighted. It has a strong potential to replace petroleum-based methylacrylic acid in industry which will create a huge market for IA.Entities:
Keywords: Aspergillus terreus; Fermentation; Itaconic acid; Platform chemical; cis-Aconitate decarboxylase
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Year: 2016 PMID： 27933436 DOI： 10.1007/s10295-016-1878-8
Source DB: PubMed Journal: J Ind Microbiol Biotechnol ISSN： 1367-5435 Impact factor: 3.346