Sam S Oh1, Randal Du1,2, Andrew M Zeiger1, Meghan E McGarry3, Donglei Hu1, Neeta Thakur1, Maria Pino-Yanes4, Joshua M Galanter1,5, Celeste Eng1, Katherine Keiko Nishimura1, Scott Huntsman1, Harold J Farber6,7, Kelley Meade8, Pedro Avila9, Denise Serebrisky10, Kirsten Bibbins-Domingo1, Michael A Lenoir11, Jean G Ford12, Emerita Brigino-Buenaventura13, William Rodriguez-Cintron14, Shannon M Thyne15, Saunak Sen16, Jose R Rodriguez-Santana17, Keoki Williams18,19, Rajesh Kumar9, Esteban G Burchard1,5. 1. a Department of Medicine , University of California San Francisco , San Francisco , CA , USA. 2. b Department of Pharmacy , University of California San Francisco , San Francisco , CA , USA. 3. c Department of Pediatrics , University of California San Francisco , San Francisco , CA , USA. 4. d Research Unit , Hospital Universitario NS de Candelaria , Santa Cruz de Tenerife , Spain. 5. e Department of Bioengineering and Therapeutic Sciences , University of California San Franscisco , San Francisco , CA , USA. 6. f Department of Pediatrics , Baylor College of Medicine , Houston , TX , USA. 7. g Department of Pulmonology , Texas Children's Hospital , Houston , TX , USA. 8. h Department of Primary Care , UCSF Benioff Children's Hospital , San Francisco , CA , USA. 9. i Department of Medicine , Northwestern University , Evanston , IL , USA. 10. j Department of Pediatric Pulmonology , Jacobi Medical Center , Bronx , NY , USA. 11. k Department of Pediatrics , Bay Area Pediatrics , Oakland , CA , USA. 12. l Department of Epidemiology , Johns Hopkins University Bloomberg School of Public Health , Baltimore , MD , USA. 13. m Department of Allergy and Immunology , Kaiser Permanente Vallejo Medical Center , San Francisco , CA , USA. 14. n Department of Pulmonary/Critica Care , VA Caribbean Healthcare System , San Juan , Puerto Rico. 15. o Department of Medicine , University of California Los Angeles David Geffen School of Medicine , Los Angeles , CA , USA. 16. p Department of Epidemiology and Biostatistics , University of California San Francisco , San Francisco , CA , USA. 17. q Department of Pediatric Pulmonology and Critical Care , Centro de Neumología Pediátrica , San Juan , Puerto Rico. 18. r Center for Health Policy and Health Services Research, Henry Ford Health System , Detroit , MI , USA. 19. s Department of Internal Medicine , Henry Ford Health System , Detroit , MI , USA.
Abstract
OBJECTIVE: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. METHODS: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8-21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. RESULTS: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. CONCLUSION: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.
OBJECTIVE: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. METHODS: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8-21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. RESULTS: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. CONCLUSION: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.
Authors: Rajesh Kumar; Max A Seibold; Melinda C Aldrich; L Keoki Williams; Alex P Reiner; Laura Colangelo; Joshua Galanter; Christopher Gignoux; Donglei Hu; Saunak Sen; Shweta Choudhry; Edward L Peterson; Jose Rodriguez-Santana; William Rodriguez-Cintron; Michael A Nalls; Tennille S Leak; Ellen O'Meara; Bernd Meibohm; Stephen B Kritchevsky; Rongling Li; Tamara B Harris; Deborah A Nickerson; Myriam Fornage; Paul Enright; Elad Ziv; Lewis J Smith; Kiang Liu; Esteban González Burchard Journal: N Engl J Med Date: 2010-07-07 Impact factor: 91.245
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Authors: Maria Pino-Yanes; Neeta Thakur; Christopher R Gignoux; Joshua M Galanter; Lindsey A Roth; Celeste Eng; Katherine K Nishimura; Sam S Oh; Hita Vora; Scott Huntsman; Elizabeth A Nguyen; Donglei Hu; Katherine A Drake; David V Conti; Andres Moreno-Estrada; Karla Sandoval; Cheryl A Winkler; Luisa N Borrell; Fred Lurmann; Talat S Islam; Adam Davis; Harold J Farber; Kelley Meade; Pedro C Avila; Denise Serebrisky; Kirsten Bibbins-Domingo; Michael A Lenoir; Jean G Ford; Emerita Brigino-Buenaventura; William Rodriguez-Cintron; Shannon M Thyne; Saunak Sen; Jose R Rodriguez-Santana; Carlos D Bustamante; L Keoki Williams; Frank D Gilliland; W James Gauderman; Rajesh Kumar; Dara G Torgerson; Esteban G Burchard Journal: J Allergy Clin Immunol Date: 2014-10-06 Impact factor: 10.793
Authors: Daniel Munblit; Diego G Peroni; Alba Boix-Amorós; Peter S Hsu; Belinda Van't Land; Melvin C L Gay; Anastasia Kolotilina; Chrysanthi Skevaki; Robert J Boyle; Maria Carmen Collado; Johan Garssen; Donna T Geddes; Ralph Nanan; Carolyn Slupsky; Ganesa Wegienka; Anita L Kozyrskyj; John O Warner Journal: Nutrients Date: 2017-08-17 Impact factor: 5.717