Differences among primary care patients with different mechanical patterns of low back pain: a cross-sectional investigation.

OBJECTIVES: To characterise and compare a persistent low back pain (LBP) population based on 4 clinical pain patterns.
DESIGN: Cross-sectional analysis of patient-reported data.
SETTING: Patients from 220 primary care practitioners in 3 cities in Ontario, Canada. PARTICIPANTS: 1020 individuals seeking LBP care. INCLUSION CRITERIA: LBP symptoms lasting 1½-12 months, or unmanageable recurrent symptoms; ages 18+years. EXCLUSION CRITERIA: pregnant/1-year postpartum; involved in active litigation or motor vehicle injury; emergent spinal presentations; pain disorder diagnosis; work injury claim; or constant symptoms persisting >12 months postonset. MAIN OUTCOME MEASURE: Hall pain pattern subgroups: back dominant pain aggravated by flexion (P1) or extension (P2), or leg dominant constant (P3) or intermittent (P4) pain (multinomial logistic outcome; referent: P1).
RESULTS: Groups P1 and P2 had the highest proportion of women. P2 and P4 had higher mean ages and comorbidity counts. P3 and P4 had higher proportions of overweight/obese individuals and lower general health scores. Adjusted models: being male and overweight/obese was associated with increased odds of being in P3 (OR 1.64 (95% CI 1.10 to 2.46), and OR 1.74 (1.13 to 2.68), respectively) and P4 (OR 1.87 (1.11 to 3.15) and OR 1.91 (1.06 to 3.42), respectively), and increasing age with increased odds of being in P2 (OR 1.02 (1.01 to 1.03)) and P4 (OR 1.06 (1.04 to 1.08)). Increasing comorbidity count was associated with increased odds of being in P2 (OR 1.14 (1.0 to 1.3)), and better general health scores with decreased odds of being in P3 (OR 0.40 (0.18 to 0.93)).
CONCLUSIONS: This is the first study to examine the 'Hall system' in a non-rehab primary care population. Subgroups classified according to this system appear to have distinct profiles. Further research is needed to better characterise and determine the prognostic implication of these clinically derived subgroups. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The large sample size and rich data set provide a basis on which research on the mechanical subgrouping of the low back pain (LBP) population can be advanced.

The study population likely represents the general LBP population seeking primary care in Ontario and Canada more generally.

Potential for selection bias as only primary care practitioners who volunteered to participate in the Inter-professional Spine Assessment and Education Clinics (ISAEC) programme were able to refer patients to the programme.

The profile of patients seeking and having access to primary care for LBP through Canada's universal publicly funded healthcare system may differ from those in jurisdictions operating under different healthcare funding regimes.

Introduction

Low back pain (LBP) is a condition of global concern.1 It is the most common cause of years lived with disability1 and one of the leading reasons for seeking primary healthcare.2–5 Estimates suggest that up to 9% of the world's population has LBP at any given time,1 and population-based studies report that 60–90% of adults will experience LBP at some point in their lifetime.6–8 Unfortunately, the prevalence and burden of LBP continue to increase.9–11 LBP is not only a burden for individuals, many of whom will experience disabling and persistent symptoms, but the associated healthcare costs and productivity losses have significant socioeconomic impacts on society as well.12–16

Eighty to ninety per cent of chronic LBP cases presenting to primary care are considered ‘non-specific’, without a known cause or readily identifiable pathology.17 18 Often, acute and chronic LBP is managed in the primary care setting as a homogeneous condition with a ‘one size fits all’ approach.19–21 Yet, it is well known that individuals with LBP can have a wide range of aetiologies and symptom profiles, and researchers have suggested LBP classifications based on diagnosis, prognosis or treatment22 in an attempt to derive more homogeneous subgroups. Identifying such subgroups has been a top priority at the International Forums for Low Back Pain Research in Primary Care since the mid-1990s.23–25 Kent and Keating26 suggest that subgrouping is an intuitive approach as many clinicians do not perceive LBP as a single condition, believing it is possible to recognise different subgroups. Identifying distinct characteristics between any proposed LBP subgroups would support the ability of primary care to provide tailored, subgroup-specific treatment approaches to optimise outcomes.27–29 Further, identifying unique subgroup characteristics would warrant additional epidemiological investigation within the LBP population with an aim of determining potentially subgroup-specific risk factors, aetiologies and/or outcomes.

In Canada, Hall et al27 demonstrated the value of subgrouping when they identified that patients who received treatment based on their classification into one of four patterns (P) of mechanical LBP (summarised as back dominant pain, ie, flexion (P1) vs extension (P2) aggravated, and constant (P3) vs intermittent (P4) leg dominant pain) reported reduced pain and medication use post-treatment as compared with patients who did not receive stratified care. This system was developed and used principally for patients with LBP being managed by a physiotherapist, but has recently been adopted for primary care provider (family physicians and nurse practitioners) clinical use and education in three different provinces in Canada: Saskatchewan, British Columbia and Ontario.30–32 The ‘Hall system’ allows for a simple and practical starting point for primary care providers to subgroup acute-to-chronic LBP and thus enable initial stratified patient management recommendations based on repetitive pain relieving directional exercise and modified activity.33

The objective of this study was to assess, in a primary care cohort of patients with LBP, whether the four subgroups of the Hall LBP classification system27 demonstrate any distinct demographic and health characteristics.

Methods

Data source

Study data were collected in clinic as part of the Inter-professional Spine Assessment and Education Clinics (ISAEC) pilot programme (http://www.isaec.org); a programme funded by the provincial Ontario Ministry of Health and Long Term Care. The purpose of ISAEC was to identify patients who reported persistent (6–52 weeks) or recurrent LBP (regardless of duration) presenting to their primary care provider (physicians and nurse practitioners), and to use an interdisciplinary shared-care model to provide timely stratified education and self-management recommendations. Two hundred and twenty primary care providers based out of three cities in Ontario, Canada (namely Toronto, Hamilton and Thunder Bay) participated in the programme and referred patients to an ISAEC clinic. This study analysed data collected from consecutive ISAEC patients between November 2012 and February 2014.

To be eligible for the ISAEC pilot programme, patients had to be 18 years of age or older and experiencing LBP-related symptoms that were either persistent, lasting from 6 weeks to 12 months, or recurring (regardless of duration). Persistent pain was defined as constant daily pain of varying intensity and recurrent pain was defined as episodic pain with a current episode no longer manageable by primary care measures compared with previous episodes. The lower time limit excluded patients experiencing acute LBP that had a favourable natural history, while the upper time limit excluded patients with persistent pain (as per our working definition) in excess of 1 year in duration.34 The principle focus of the ISAEC programme is education and enabling patient and primary care providers to use chronic disease self-management principles to manage their LBP and mitigate chronicity. Patients were ineligible if they had a work-based insurance claim, were in pain following a motor vehicle accident, had established narcotic dependency (ie, those actively being managed by a pain specialist), were involved in active litigation, were pregnant/postpartum (<1 year), had emergent spinal presentations or had an established diagnosis of a pain disorder.

LBP classification

The subgrouping of patients with LBP with mechanical ‘non-specific’ symptoms was based on the classification system proposed by Hall et al.27 The system relies on patient history and physical examination. A trained advanced practice clinician (APC) assessed patients. The dominant symptoms were classified by the APCs into one of four pain pattern subgroups: back dominant pain aggravated by flexion (P1), back dominant pain aggravated by extension (P2), constant leg dominant pain (P3) and intermittent leg dominant pain (P4). When applied by physiotherapists, inter-rater reliability for this system has been reported at 79% (κ=0.61).35 Half of the ISAEC APCs were physiotherapists and the other half chiropractors. All APCs underwent a 13-week hands-on training curriculum (one full day per week) to ensure that the clinicians participating in the ISAEC programme had the appropriate interprofessional training to understand the full continuum of LBP assessment and care from the context of primary and specialty care. This included education in the clinics of spine surgeons, a physiatrist, a rheumatologist, primary care doctors and a pain psychologist; interprofessional best practice education sessions; and a final examination that included assessment of the APCs ability to effectively use the Hall classification system and the ISAEC management protocols.

Questionnaire data

Patients attending ISAEC completed an intake questionnaire prior to consulting with a member of the ISAEC clinical team. All responses were self-reported. Patients reported their current age (years), sex, and height and weight, from which body mass index (BMI; kg/m2) was calculated. Individuals were categorised as normal (BMI<24.99), overweight (25≤BMI<29.99) or obese (BMI≥30).

Prevalent comorbidities were elicited using the Self-Administered Comorbidity Questionnaire,36 whereby patients were presented with a list of conditions (high cholesterol; high blood pressure; cardiovascular disease (stroke; heart disease/coronary artery disease; peripheral vascular disease); asthma/chronic obstructive pulmonary disease; diabetes; ulcer or stomach disease; cancer; depression; anxiety, bipolar disorder, obsessive compulsive disorder and panic disorder; osteoarthritis; rheumatoid arthritis) with a request to indicate all that were applicable. A comorbidity count was derived.

Patients indicated whether or not they had a history of back problems (yes, no).

Disability was assessed with the Oswestry Disability Index, a widely used and validated, spine-specific disability measure for patients with LBP.37–40 The measure includes 10 items that assess pain intensity and interference with general movement, personal care, sleeping, social life, travelling and work. Patients respond to each item using a 0–5 scale. The sum of the 10 scores is reported as a percentage of the total possible score (maximum of 50) with higher percentages indicating greater disability.

The EuroQol-5D, a generic, validated questionnaire, was used to assess overall health-related quality of life.41 42 The questionnaire elicits level of severity, rated 1 (no problems), 2 (some/moderate problems) or 3 (extreme problems), for each of five health dimensions: mobility, self-care, daily activities, pain/discomfort and anxiety/depression. A summary score is generated by applying published weights to each of the 243 possible health states.43 A value-adjusted summary score of 100 indicates that, on the day that the questionnaire was completed, the patient had no problems on any of the five items, while lower value-adjusted summary scores indicate some degree of problems and poorer self-rated health.

Statistical analyses

Descriptive statistics were generated for each of the study measures by clinical LBP pattern subgroup: mean and SD were calculated for age, BMI, number of chronic conditions, Oswestry per cent disability and EuroQol-5D summary score, and proportions for sex, age groups, BMI categories and history of back problems. Statistical comparisons across subgroups were made by way of analysis of variance (age, BMI, number of chronic conditions, Oswestry per cent disability and EuroQol-5D summary score), Fisher's exact test (age group) and χ2 test (sex, BMI category and history of back problems).

An adjusted multinomial regression analysis was undertaken to identify factors associated with clinical pain pattern subgroups. The focus was on identifying non-back-specific factors which potentially distinguished between back pain pattern subgroups. The factors included demographic (age and sex) and health characteristics (overweight/obese vs normal, number of chronic conditions and EuroQol-5D summary score). The four clinical LBP subgroups constituted the model outcome with ‘back pain aggravated by flexion’ (P1) used as the referent category; P1 was chosen as it was the largest subgroup.

Statistical analyses were conducted using RStudio software (V.0.98.507, RStudio, Boston, Massachusetts, USA). Statistical probability levels ≤0.05 were deemed as statistically significant.

Patient involvement

Patient engagement was not elicited for this specific study. However, active patient engagement in the form of focus groups preimplementation and postimplementation of the ISAEC pilot programme has been an integral part of the development and ongoing improvement of the ISAEC programme.

Results

During the study time period, 1197 patients were referred to an ISAEC clinic; 64 of these were subsequently deemed ineligible for the programme. Data were available for 970 patients (85.6%) for this study (figure 1). The mean age of the sample was 50 years (SD 15.7); 56% were women. By pain pattern subgroup, 405 patients were categorised as P1 (42%), 301 (31%) as P2, 164 (17%) as P3 and 100 (10%) as P4.

Figure 1

Patient flow diagram. ISAEC, Inter-professional Spine Assessment and Education Clinics.

Descriptive statistics for the sample are presented in table 1 by pain pattern subgroup. Overall, ages ranged from 18 to 93 years, with mean subgroup-specific ages ranging from 46 to 63 years. Statistically significant differences between at least one subgroup and the others were observed for several factors. The P2 and P4 groups had a higher proportion of older individuals, while the proportion of women was higher in the P1 and P2 groups.

Table 1

Demographic factors and health measures describing the study population stratified by pain pattern subgroup

	LBP subgroups based on clinical presentation (n=970)
	Back dominant pain aggravated by flexion (P1) (n=405; 42%)	Back dominant pain aggravated by extension (P2) (n=301; 31%)	Constant leg dominant pain (P3) (n=164; 17%)	Intermittent leg dominant pain (P4) (n=100; 10%)	p Value*
Demographic factors
Sex (% female)	59	61	46	46	0.001
Mean age (range)	46.2±14.4(18–85)	51.6±16.6(18–93)	47.4±13.3, (19–85)	62.9±14.1(31–92)	<0.001
Age groups (%)					<0.001
18–29	14	11	7	0
30–39	23	16	24	6
40–49	24	18	29	12
50–59	20	21	21	22
60+	20	34	20	60
Mean body mass index (kg/m2)	26.4±5.5	27.6±6.3	28.1±6.0	28.4±5.5	<0.001
Body mass index categories (%)					0.004
Normal weight (<25)	47	41	32	24
Overweight (25–29.9)	33	30	41	46
Obese (≥30)	20	29	27	31
Health measures
Mean number of chronic conditions (range)	1.0±1.3 (0–11)	1.4±1.5 (0–10)	1.0±1.3 (0–5)	1.9±1.8 (0–7)	<0.001
History of back problems (% yes)	58	50	59	59	0.141
Mean Oswestry per cent disability†	33.3±17.2	33.7±17.7	44.4±19.1	38.2±17.8	<0.001
Mean EuroQol-5D summary score‡	66.0±21.4	65.5±20.3	56.9±22.7	61.6±20.0	<0.001

Data presented as mean±SD where indicated.

*p Value for χ2, analysis of variance or Fisher's exact test where appropriate.

†Higher percentage indicates greater disability.

‡Scores decreasing from 100 indicate poorer health-related quality of life.

LBP, low back pain.

Significant differences in BMI were found, with the P2 and P4 groups having higher proportions of obese individuals. The P2 and P4 groups also had higher mean comorbidity counts. Finally, the P3 group had the highest (ie, worse) mean Oswestry Disability Index scores and lowest overall health-related quality of life scores.

Considering age, sex, BMI, the number of comorbidities and general health status scores, results from the multinomial logistic regression analysis suggest distinct features between LBP subgroups (table 2). Increasing age was associated with increased odds of being in the P2 (OR 1.02 (95% CI 1.01 to 1.03)) and P4 groups (OR 1.06 (95% CI 1.04 to 1.08)), relative to the P1 group. Being male was associated with increased odds of being in the P3 (OR 1.64 (95% CI 1.1 to 2.46)) and P4 groups (OR 1.87 (95% CI 1.11 to 3.15)). Compared with those with normal BMI, overweight/obese individuals had increased odds of being in the P3 group (OR 1.74 (95% CI 1.13 to 2.68)) and P4 group (OR 1.91 (95% CI 1.06 to 3.42)). Increasing number of chronic conditions was associated with increased odds of being in the P2 group (OR 1.14 (95% CI 1.00 to 1.30)). Finally, higher EuroQol-5D score (ie, better health) was associated with decreased odds of being in the P3 group (OR 0.40 (95% CI 0.18 to 0.93)).

Table 2

Multinomial logistic regression results; outcome: pain pattern subgroup*

Factor	Subgroup	OR	95% CI	p Value
Age (years)
	Back extension	1.02	1.01 to 1.03	0.002
	Constant leg	1.00	0.99 to 1.02	0.626
	Intermittent leg	1.06	1.04 to 1.08	<0.001
Sex
Male (Ref: female)	Back extension	0.90	0.64 to 1.27	0.551
	Constant leg	1.64	1.10 to 2.46	0.017
	Intermittent leg	1.87	1.11 to 3.15	0.018
Body mass index
Overweight/obese (Ref: normal)	Back extension	1.19	0.84 to 1.68	0.322
	Constant leg	1.74	1.13 to 2.68	0.012
	Intermittent leg	1.91	1.06 to 3.42	0.031
Number of chronic conditions†
	Back extension	1.14	1.00 to 1.30	0.045
	Constant leg	0.93	0.78 to 1.10	0.400
	Intermittent leg	1.13	0.95 to 1.34	0.186
EuroQol-5D summary score
	Back extension	1.86	0.86 to 4.00	0.113
	Constant leg	0.40	0.18 to 0.93	0.033
	Intermittent leg	0.56	0.18 to 1.69	0.301

*‘Back flexion’ is referent group.

†Comorbidity count developed based on those conditions with at least 5% prevalence in the sample (high cholesterol, high blood pressure, diabetes, depression, osteoarthritis, and asthma/chronic obstructive pulmonary disease).

Discussion

This study is the first to assess the discriminatory ability of the Hall mechanical LBP classification system in a non-rehabilitation primary care setting. Among patients assessed in the ISAEC shared-care primary care network, we found differences in demographic and specific health characteristics between subgroups classified according to dominant LBP patterns as described by Hall et al.27 Differences persisted following adjusted analysis, in which we identified unique and independent associations with age, sex, BMI, number of chronic conditions and self-rated health status.

The most clinically distinct observations were that increasing age and number of comorbidities were associated with the back pain with extension (P2) and/or intermittent leg pain (P4) groups. For every 1 year increase in age, the odds increased by 2% and 6% for P2 and P4, representing a 22% and 79%, respectively, increased odds for each decade of age. Every unit increase in comorbidity count increased the odds of being in P2 by 14%. Patients in P2 and P4 present with mechanical symptom patterns which, in the absence of other symptoms or signs to suggest red flags (ie, tumour, infection or fracture), represent symptomatic spine osteoarthritis (ie, extension dominant symptom provocation) that are typical of symptoms of lumbar spinal stenosis (ie, back pain and/or neurogenic claudication) which is due to facet osteoarthritic changes and posterior spinal element loading in extension.44–47 Studies have identified that increasing age48–52 and number of comorbidities53–55 are generally associated with osteoarthritis. Our findings indicate that men were more likely to present with leg dominant symptoms than women. While the female sex is a known risk factor for osteoarthritis of the hand, hip and knee,50 52 56 57 the association with lumbar spine osteoarthritis is not as clear,45 57–59 and there is mixed evidence regarding the association between facet joint osteoarthritis and back pain.49 51 60 61 It is noted by Hall et al that P4 represents the clinical syndrome of neurogenic claudication. However, they did not speculate on the pathoanatomic aetiology of P2 and also note that their classification by dominant pain pattern is not designed to make inference to a pathoanatomical source of pain.27 Whether our findings truly indicate a greater likelihood of an underlying osteoarthritis aetiology for the P2 and P4 groups would require advanced imaging and symptom correlation. However, this is likely to be a costly and unreliable exercise, given the well-known poor correlation of back symptoms and the pathoanatomical changes noted in spinal imaging.11 In fact, one of the mandates of the ISAEC programme is to reduce unnecessary imaging by using valid clinical tools to enable stratified care. Anecdotally, for those with P4 symptoms that went on to surgical assessment and imaging, the anatomical diagnosis of spinal stenosis was confirmed. Finally, our finding that P3 pain (constant leg pain, typically termed ‘sciatica’) was associated with worse self-rated health status is not surprising, given the typically severe degree of pain and disability associated with the clinical syndrome of radiculopathy.62

This study was based on a patient population drawn from three cities in different regions of Ontario, Canada and from the practices of 220 primary care practitioners. Thus, our sample likely represents the general chronic LBP population seeking primary care in Ontario, the most populous province in Canada, and likely Canada generally. However, only patients of primary care practitioners who volunteered to participate in the ISAEC programme were available to this study, which may have introduced an element of selection bias. Furthermore, Canadians have a universal publicly funded healthcare system and the profile of patients seeking and having access to primary care for LBP may differ from those in jurisdictions operating under different healthcare funding regimes. It is also worth noting that estimates of inter-rater reliability for the Hall classification system have been published for physiotherapists but not for chiropractors. This raises a limitation of this study since potential variability in how chiropractor APCs (half of all ISAEC APCs) applied the Hall classification system was not evaluated and cannot be inferred from other studies. Additionally, for cases where patients' reporting of pain dominance was ambiguous or the pattern was potentially mixed, the APCs rephrased the symptom questions in multiple iterations to establish which symptom or aggravating factor was most functionally limiting and therefore determined the dominant pattern. The prevalence of this uncommon scenario was not objectively captured. Nevertheless, our findings, based on a large primary care sample and rich data set, provide an important basis on which research in the subgrouping of the LBP population can be advanced. While findings specific to two of the four subgroups suggest a potentially greater likelihood of underlying osteoarthritis, an objective identification of spine osteoarthritis (ie, cross-sectional spinal imaging), or otherwise generalised osteoarthritis, was not documented.

Establishing the utility of any subgrouping system relies on a clear understanding and description of its intended purpose(s). In 2011, Fairbank et al22 published a systematic review of LBP classification systems and identified a total of 28 systems that were either descriptive, prognostic or intended to guide treatment. In September 2014, the National Institutes for Health Task Force for Research Standards for Chronic Low Back Pain published a report recommending that chronic LBP be stratified based on impact,63 where impact was defined as a combined measure of pain intensity, functional status, and pain interference with normal activities. While this system may be useful for research purposes, the authors state that further investigation of the clinical utility of this stratification system is necessary. While the clinical utility of the system used for the present study has been reported for treatment purposes,27 our work suggests that this system may facilitate research as well, particularly at identifying unique, more homogeneous subgroups, with the goal of elucidating aetiology and facilitating group-specific risk management. For example, in addition to directional exercise and activity modification as suggested by Hall et al, a clinical diagnosis of spinal osteoarthritis for P2 and P4 patients can also allow for more targeted medical management, such as more aggressive use of non-steroidal anti-inflammatory drugs, or more appropriate surgical referrals for patients with P4 without the need for advanced imaging.30 64 65 This study has uniquely assessed the Hall system in a broader LBP population that, as noted above, is more representative of the primary care spectrum of chronic LBP. The study by Hall and colleagues evaluated a mixed group of patients assessed in an outpatient rehabilitation setting, suggesting that only patients with insurance coverage or the ability to self-pay were included, and thereby potentially introducing selection bias into the study. In contrast, our primary care cohort was situated within a universally funded health system. In the present study, older individuals were more likely to present with dominant symptoms consistent with the P2 and P4 pain patterns. Interestingly, these two groups comprised 31% and 10% of the current cohort, compared with 7.8% and 1.5%, respectively, of patients enrolled in the study by Hall et al.27 For the latter study, barriers, including socioeconomic, to rehabilitation/exercise in the older population66 may explain some of the comparative discrepancy. We are not aware of any other studies that have evaluated other classification systems for distinct epidemiological profiles that may aid in further subgroup stratification.

The current primary care paradigm emphasises providing patient-focused, ‘personalised’ care, but also conserving limited health resources. Several existing classification systems involve complex criteria that cannot be quickly evaluated during a physician consultation,67 require expensive diagnostic tests or may not be feasible within the primary care setting.22 The classification system we adopted can be easily integrated in the clinical setting with good reliability since it has few and distinct categories that are simple to elicit from patients (ie, dominance and mechanical aspect of an individual's pain)27 facilitating initial treatment decision-making for primary care practitioners with minimal added time and resource requirements. To the best of our knowledge, this is the largest study to describe the primary care seeking (medical doctor or nurse practitioner) persistent LBP population stratified by the proposed subgrouping system. It is the first study to identify unique patient and health characteristic correlates for these subgroups, with similar features in the P2 and P4 group suggestive of spinal osteoarthritis. Concluding similarly as have others,21 23–25 a stratified approach to LBP, rather than the conventional non-specific approach, is supported for the clinical and research settings. For clinical and research purposes, a critical component of any classification system is the ability to differentiate between subclasses. For research, these pain pattern subgroupings may facilitate improved investigations of aetiology and identification of group-specific risk factors. Although not the focus of this paper, in other collaborative work by Alleyne et al,33 we have noted ease of clinical translation of the Hall classification system to primary care providers with minimal training (online or in person session) and/or the use of a simple one page clinical tool (Clinically Organized Relevant Exam (CORE) Tool for the Low Back Pain). Clinically, subgroup-specific treatment based on this system has been shown to result in improved health outcomes, including fewer treatment days and significantly greater odds of no pain or medication use post-treatment compared with patients experiencing more homogeneous care.27 Randomised controlled trials comparing two alternate subgroup-specific treatment approaches to standard unstratified care for patients with acute/subacute or subacute/chronic LBP identified that subgroup-specific treatment was equally or more effective at reducing short-term and long-term disability.28 68 69

Despite considerable investment in research and numerous clinical practice guidelines, the burden of LBP continues to increase.10 11 Recognising that the aetiology, course and/or outcomes of LBP can be highly variable,70–73 there is a critical need for an optimal disentanglement of this large clinical population. Ongoing optimisation of subgrouping distinct patient phenotypes with the potential to guide clinical management within the LBP population will have tremendous research and clinical impact. Our work suggests that stratification of LBP subgroups based on the aforementioned pain patterns appears viable and able to provide clinically relevant stratification in the primary care, non-rehabilitation LBP population. In addition, it provides a practical clinical starting point that can be easily added to subgrouping on the basis of chronicity risk28 and/or impact.63 Further, longitudinal comparative and prognostic evaluation work is required and has begun concurrently to this study.