Adina E Feinberg1, Tyler R Chesney, Sergio A Acuna, Tarik Sammour, Fayez A Quereshy. 1. 1 Department of Surgery, University of Toronto, Toronto, Ontario, Canada 2 Institute of Health Policy, Management and Education, University of Toronto, Toronto, Ontario, Canada 3 Department of Surgery, The Royal Melbourne Hospital, Melbourne, Victoria, Australia 4 Department of Surgical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Abstract
BACKGROUND: Locally advanced colon cancer is considered a relative contraindication for laparoscopic resection, and clinical trials addressing the oncologic safety are lacking. OBJECTIVE: The aim of this study was to synthesize the oncologic outcomes associated with laparoscopic versus conventional open surgery for locally advanced colon cancers. DATA SOURCES: We systematically searched Medline, Embase, Central, and ClinicalTrials.gov. STUDY SELECTION: Two reviewers independently screened the literature for controlled trials or observational studies comparing curative-intent laparoscopic and open surgery for colon cancer. Studies were included if it was possible to determine outcomes for the T4 colon cancers separately, either reported in the article or calculated with individual patient data. INTERVENTIONS: Included studies were systematically reviewed and assessed for risk of bias. Meta-analyses were done by using random-effects models. MAIN OUTCOME MEASURES: Outcomes of interest were disease-free survival, overall survival, resection margins, and lymph node harvest. RESULTS: Of 2878 identified studies, 5 observational studies met eligibility criteria with a total of 1268 patients (675 laparoscopic, 593 open). There was no significant difference in overall survival (HR, 1.28; 95% CI, 0.94-1.72), disease-free survival (HR, 1.20; 95% CI, 0.90-1.61), or positive surgical margins (OR, 1.16; 95% CI, 0.58-2.32) between the groups. The open group had a larger lymph node retrieval (pooled mean difference, 2.26 nodes; 95% CI, 0.58-3.93). The pooled rate of conversion from laparoscopy to an open procedure was 18.6% (95% CI, 9.3%-27.9%). LIMITATIONS: These results are limited by the inherent selection bias in the included nonrandomized studies. CONCLUSIONS: Based on the available literature, minimally invasive resection of selected locally advanced colon cancer is oncologically safe. There is a small increase in lymph node harvest with open resections, but it is unclear whether this is clinically significant. Surgeons should be prepared for a significant rate of conversion to laparotomy as required to perform en bloc resection.
BACKGROUND: Locally advanced colon cancer is considered a relative contraindication for laparoscopic resection, and clinical trials addressing the oncologic safety are lacking. OBJECTIVE: The aim of this study was to synthesize the oncologic outcomes associated with laparoscopic versus conventional open surgery for locally advanced colon cancers. DATA SOURCES: We systematically searched Medline, Embase, Central, and ClinicalTrials.gov. STUDY SELECTION: Two reviewers independently screened the literature for controlled trials or observational studies comparing curative-intent laparoscopic and open surgery for colon cancer. Studies were included if it was possible to determine outcomes for the T4 colon cancers separately, either reported in the article or calculated with individual patient data. INTERVENTIONS: Included studies were systematically reviewed and assessed for risk of bias. Meta-analyses were done by using random-effects models. MAIN OUTCOME MEASURES: Outcomes of interest were disease-free survival, overall survival, resection margins, and lymph node harvest. RESULTS: Of 2878 identified studies, 5 observational studies met eligibility criteria with a total of 1268 patients (675 laparoscopic, 593 open). There was no significant difference in overall survival (HR, 1.28; 95% CI, 0.94-1.72), disease-free survival (HR, 1.20; 95% CI, 0.90-1.61), or positive surgical margins (OR, 1.16; 95% CI, 0.58-2.32) between the groups. The open group had a larger lymph node retrieval (pooled mean difference, 2.26 nodes; 95% CI, 0.58-3.93). The pooled rate of conversion from laparoscopy to an open procedure was 18.6% (95% CI, 9.3%-27.9%). LIMITATIONS: These results are limited by the inherent selection bias in the included nonrandomized studies. CONCLUSIONS: Based on the available literature, minimally invasive resection of selected locally advanced colon cancer is oncologically safe. There is a small increase in lymph node harvest with open resections, but it is unclear whether this is clinically significant. Surgeons should be prepared for a significant rate of conversion to laparotomy as required to perform en bloc resection.
Authors: Piera Leon; Michele Giuseppe Iovino; Fabiola Giudici; Antonio Sciuto; Nicolò de Manzini; Diego Cuccurullo; Francesco Corcione Journal: Surg Endosc Date: 2017-08-25 Impact factor: 4.584
Authors: Javier Mar; Ane Anton-Ladislao; Oliver Ibarrondo; Arantzazu Arrospide; Santiago Lázaro; Nerea Gonzalez; Marisa Bare; Daniel Callejo; Maximino Redondo; José M Quintana Journal: Surg Endosc Date: 2018-06-04 Impact factor: 4.584
Authors: Karin Atgm Wasmann; Charlotte El Klaver; Jarmila Dw van der Bilt; Susan van Dieren; Iris D Nagtegaal; Cornelis Ja Punt; Bert van Ramshorst; Albert M Wolthuis; Johannes Hw de Wilt; André D'Hoore; Hjalmar C van Santvoort; Pieter J Tanis Journal: Cancer Manag Res Date: 2019-07-29 Impact factor: 3.989