Vassilis Kouloulias1, Eftychia Mosa2, Anna Zygogianni3, Efrosini Kypraiou2, John Georgakopoulos2, Kalliopi Platoni2, Christos Antypas3, George Kyrgias4, Maria Tolia5, Christos Papadimitriou6, Amanda Psyrri7, George Patatoukas2, Maria Dilvoi2, Christina Armpilia3, Kyriaki Theodorou4, Maria-Aggeliki Kalogeridi4, Ivelina Beli2, John Kouvaris3, Nikolaos Kelekis2. 1. Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece; Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece. 2. Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece. 3. Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece. 4. Radiotherapy Department, Medical School of Thessaly, University Hospital of Larisa, Larisa, Greece, Athens, Greece. 5. Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece; Radiotherapy Department, Medical School of Thessaly, University Hospital of Larisa, Larisa, Greece, Athens, Greece. 6. Therapeutics Clinic, Alexandra Hospital, Medical School of Athens, Athens, Greece, Athens, Greece. 7. Medical Oncology Unit, ATTIKON University Hospital, Athens, Greece.
Abstract
INTRODUCTION: The aim of this analysis was a retrospective evaluation of the efficacy and toxicity of 2 hypofractionated irradiation schedules compared to conventional therapy in post-mastectomy patients. METHODS: 3 irradiation schedules were analyzed: 48.30 Gy in 21 fractions (group A, n = 60), 42.56 Gy in 16 fractions (group B, n = 27) and 50 Gy in 25 fractions (group C, n = 30) of the front chest wall. All groups were also treated with a supraclavicular field, with 39.10 Gy in 17 fractions (group A), 37.24 Gy in 14 fractions (group B) or 45 Gy in 25 fractions (group C). RESULTS: No local recurrences were noted in any group during 36 months of follow-up. Acute skin toxicity presented in all groups, with 58.3%, 70.4% and 60% of grade I; 35%, 25.9% and 40% of grade II; 6.7%, 3.7% and 0% of grade III being seen in groups A, B and C, respectively. Late skin toxicity was noted only as grade I in 16.7%, 25.9% and 26.7% of groups A, B and C, respectively. No significant difference was noted among all groups for either acute or late skin toxicity, or for radio-pneumonitis (chi2 test, p > 0.05). CONCLUSION: All schedules were equally effective with equivalent toxicity. A prospective randomized study is needed to confirm our results.
INTRODUCTION: The aim of this analysis was a retrospective evaluation of the efficacy and toxicity of 2 hypofractionated irradiation schedules compared to conventional therapy in post-mastectomy patients. METHODS: 3 irradiation schedules were analyzed: 48.30 Gy in 21 fractions (group A, n = 60), 42.56 Gy in 16 fractions (group B, n = 27) and 50 Gy in 25 fractions (group C, n = 30) of the front chest wall. All groups were also treated with a supraclavicular field, with 39.10 Gy in 17 fractions (group A), 37.24 Gy in 14 fractions (group B) or 45 Gy in 25 fractions (group C). RESULTS: No local recurrences were noted in any group during 36 months of follow-up. Acute skin toxicity presented in all groups, with 58.3%, 70.4% and 60% of grade I; 35%, 25.9% and 40% of grade II; 6.7%, 3.7% and 0% of grade III being seen in groups A, B and C, respectively. Late skin toxicity was noted only as grade I in 16.7%, 25.9% and 26.7% of groups A, B and C, respectively. No significant difference was noted among all groups for either acute or late skin toxicity, or for radio-pneumonitis (chi2 test, p > 0.05). CONCLUSION: All schedules were equally effective with equivalent toxicity. A prospective randomized study is needed to confirm our results.
Entities:
Keywords:
Breast cancer; Efficacy; Hypofractionation; Postmastectomy irradiation; Toxicity
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