PURPOSE: To evaluate the acute and late effects as well as the cosmetic results of an accelerated hypofractionated radiotherapeutic schedule in breast cancer irradiation. METHODS: Fifty-four patients with stage I-II invasive breast cancer receiving postoperative radiotherapy (RT) after lumpectomy and axillary node dissection were studied. All patients received RT with 6 MV linear accelerator with a total tumor dose of 53 Gy (Equivalent dose-EQD2- 60 Gy), 2.65 Gy per fraction, in 20 fractions. Acute and late effects as well as cosmetic results were assessed using the European Organization for Research and Treatment of Cancer and Radiation Therapy Oncology Group (EORTC-RTOG) Cosmetic Rating System. RESULTS: By the end of RT 66.7% of the patients developed no toxicity, while 24.1% showed grade 1 and 9.3% grade 2 acute skin toxicity. After 6 months 90.7% of women showed grade 0 late toxicity while 100% of women recovered completely 2 years after RT. There was no local or distant recurrence during 5-year follow up. CONCLUSION: The accelerated hypofractionated schedule appears to be an acceptable alternative to the traditional longer RT schedules, without late toxicity.
PURPOSE: To evaluate the acute and late effects as well as the cosmetic results of an accelerated hypofractionated radiotherapeutic schedule in breast cancer irradiation. METHODS: Fifty-four patients with stage I-II invasive breast cancer receiving postoperative radiotherapy (RT) after lumpectomy and axillary node dissection were studied. All patients received RT with 6 MV linear accelerator with a total tumor dose of 53 Gy (Equivalent dose-EQD2- 60 Gy), 2.65 Gy per fraction, in 20 fractions. Acute and late effects as well as cosmetic results were assessed using the European Organization for Research and Treatment of Cancer and Radiation Therapy Oncology Group (EORTC-RTOG) Cosmetic Rating System. RESULTS: By the end of RT 66.7% of the patients developed no toxicity, while 24.1% showed grade 1 and 9.3% grade 2 acute skin toxicity. After 6 months 90.7% of women showed grade 0 late toxicity while 100% of women recovered completely 2 years after RT. There was no local or distant recurrence during 5-year follow up. CONCLUSION: The accelerated hypofractionated schedule appears to be an acceptable alternative to the traditional longer RT schedules, without late toxicity.
Authors: Vassilis Kouloulias; Eftychia Mosa; Anna Zygogianni; Efrosini Kypraiou; John Georgakopoulos; Kalliopi Platoni; Christos Antypas; George Kyrgias; Maria Tolia; Christos Papadimitriou; Amanda Psyrri; George Patatoukas; Maria Dilvoi; Christina Armpilia; Kyriaki Theodorou; Maria-Aggeliki Kalogeridi; Ivelina Beli; John Kouvaris; Nikolaos Kelekis Journal: Breast Care (Basel) Date: 2016-09-28 Impact factor: 2.860
Authors: V Kouloulias; C Asimakopoulos; M Tolia; G Filippou; K Platoni; M Dilvoi; I Beli; J Georgakopoulos; G Patatoukas; N Kelekis Journal: Hippokratia Date: 2013-04 Impact factor: 0.471