Gloria Lena Vega1, Scott M Grundy2, Carolyn E Barlow3, David Leonard3, Benjamin L Willis3, Laura F DeFina3, Stephen W Farrell3. 1. Departments of Clinical Nutrition and Internal Medicine, Center for Human Nutrition of the University of Texas Southwestern Medical Center, Dallas, TX, USA; The Veterans Administration North Texas Health Care System, Dallas, TX, USA. Electronic address: Gloria.Vega@utsouthwestern.edu. 2. Departments of Clinical Nutrition and Internal Medicine, Center for Human Nutrition of the University of Texas Southwestern Medical Center, Dallas, TX, USA; The Veterans Administration North Texas Health Care System, Dallas, TX, USA. 3. The Cooper Institute, Dallas, TX, USA.
Abstract
BACKGROUND: Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. OBJECTIVE: To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. METHODS: Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth. RESULTS: Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5% per year in low CRF population, compared with 1.7% in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors. CONCLUSION: A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio. Copyright Â
BACKGROUND: Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. OBJECTIVE: To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. METHODS: Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth. RESULTS:Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5% per year in low CRF population, compared with 1.7% in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors. CONCLUSION: A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio. Copyright Â
Authors: Nisha Hosadurg; Brittany M Bogle; Golsa Joodi; Murrium I Sadaf; Irion Pursell; Philip M Mendys; John P Mounsey; Ross J Simpson Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2018-08-24