Martine M Perrigue1, Adam Drewnowski2, Ching-Yun Wang1, Xiaoling Song1,3, Mario Kratz1,4,5, Marian L Neuhouser1,2. 1. a Cancer Prevention Program , Fred Hutchinson Cancer Research Center , Seattle , Washington , USA. 2. b Nutritional Sciences Program , School of Public Health, University of Washington , Seattle , Washington , USA. 3. c Translational Research Program , Fred Hutchinson Cancer Research Center , Seattle , Washington , USA. 4. d Department of Epidemiology , School of Public Health, University of Washington , Seattle , Washington , USA. 5. e Department of Medicine , University of Washington , Seattle , Washington , USA.
Abstract
BACKGROUND: Eating frequency (EF) may influence obesity-related disease risk by attenuating postprandial fluctuations in hormones involved in metabolism, appetite regulation, and inflammation. MATERIALS/ METHODS: This randomized crossover intervention trial tested the effects of EF on fasting plasma insulin-like growth factor-I (IGF-1) and leptin. Fifteen subjects (4 males, 11 females) completed twoeucaloric intervention phases lasting 21 days each: low EF ("low-EF"; 3 eating occasions/day) and high EF ("high-EF"; 8 eating occasions/day). Subjects were free-living and consumed their own meals using individualized structured meal plans with instruction from study staff. Subjects completed fasting blood draws and anthropometry on the first and last day of each study phase. The generalized estimated equations modification of linear regression tested the intervention effect on fasting serum IGF-1 and leptin. RESULTS:Mean (± SD) age was 28.5 ± 8.70 years, and mean (± SD) Body Mass Index was 23.3 (3.4) kg/m2. We found lower mean serum IGF-1 following the high-EF condition compared to the low-EF condition (P < 0.001). There was no association between EF and plasma leptin (P = 0.83). CONCLUSION: These results suggest that increased EF may lower serum IGF-1, which is a hormonal biomarker linked to increased risk of breast, prostate, and colorectal cancer.
RCT Entities:
BACKGROUND: Eating frequency (EF) may influence obesity-related disease risk by attenuating postprandial fluctuations in hormones involved in metabolism, appetite regulation, and inflammation. MATERIALS/ METHODS: This randomized crossover intervention trial tested the effects of EF on fasting plasma insulin-like growth factor-I (IGF-1) and leptin. Fifteen subjects (4 males, 11 females) completed two eucaloric intervention phases lasting 21 days each: low EF ("low-EF"; 3 eating occasions/day) and high EF ("high-EF"; 8 eating occasions/day). Subjects were free-living and consumed their own meals using individualized structured meal plans with instruction from study staff. Subjects completed fasting blood draws and anthropometry on the first and last day of each study phase. The generalized estimated equations modification of linear regression tested the intervention effect on fasting serum IGF-1 and leptin. RESULTS: Mean (± SD) age was 28.5 ± 8.70 years, and mean (± SD) Body Mass Index was 23.3 (3.4) kg/m2. We found lower mean serum IGF-1 following the high-EF condition compared to the low-EF condition (P < 0.001). There was no association between EF and plasma leptin (P = 0.83). CONCLUSION: These results suggest that increased EF may lower serum IGF-1, which is a hormonal biomarker linked to increased risk of breast, prostate, and colorectal cancer.
Authors: Rania A Mekary; Frank B Hu; Walter C Willett; Stephanie Chiuve; Kana Wu; Charles Fuchs; Teresa T Fung; Edward Giovannucci Journal: Am J Epidemiol Date: 2012-03-02 Impact factor: 4.897
Authors: Martine M Perrigue; Elizabeth D Kantor; Theresa A Hastert; Ruth Patterson; John D Potter; Marian L Neuhouser; Emily White Journal: Cancer Causes Control Date: 2013-09-21 Impact factor: 2.506
Authors: D J Jenkins; T M Wolever; V Vuksan; F Brighenti; S C Cunnane; A V Rao; A L Jenkins; G Buckley; R Patten; W Singer Journal: N Engl J Med Date: 1989-10-05 Impact factor: 91.245
Authors: Marian L Neuhouser; Catherine Clowry; Sarah J Beatty; Ching-Yun Wang; Adam Drewnowski; Martine M Perrigue Journal: Contemp Clin Trials Commun Date: 2019-02-15
Authors: Marian L Neuhouser; Betsy C Wertheim; Martine M Perrigue; Melanie Hingle; Lesley F Tinker; James M Shikany; Karen C Johnson; Molly E Waring; Rebecca A Seguin-Fowler; Mara Z Vitolins; Eliezer Schnall; Linda Snetselaar; Cynthia Thomson Journal: Curr Dev Nutr Date: 2020-07-21